Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects
Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects
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DOI：
10.5650/jos.62.873
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发表时间：
2013-11-01
影响因子：
1.5
通讯作者：
Miyazawa, Teruo
中科院分区：
文献类型：
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作者：
Miyazawa, Taiki;Nakagawa, Kiyotaka;Miyazawa, Teruo
红细胞膜中磷脂过氧化氢(PLOOH)的积聚是老年痴呆患者的一种异常现象，包括阿尔茨海默病患者。在我们之前的研究中，假设饮食中的叶黄素(叶黄素等极性类胡萝卜素)可以抑制脂质过氧化。在本研究中，我们进行了一项随机、双盲、安慰剂对照的人体试验，以评估总共2个月的小球藻补充剂(8g小球藻/天/人；相当于22.9毫克叶黄素/天/人)对12名正常老年人红细胞和血浆中PLOOH和类胡萝卜素浓度的影响。治疗1或2个月后，小球藻组的红细胞和血浆中的叶黄素浓度升高，而安慰剂组则没有。补充小球藻组，治疗2个月后红细胞PLOOH浓度低于补充前水平。这些结果表明，小球藻的摄入改善了红细胞的抗氧化状态，降低了PLOOH浓度。这些减少可能有助于维持红细胞的正常功能，防止老年痴呆症的发展。
Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer's disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact for a total of 2 months Chlorella supplementation (8 g Chlorella/day/person; equivalent to 22.9 mg lutein/day/person) on PLOOH and carotenoid concentrations in erythrocytes as well as plasma of 12 normal senior subjects. After 1 or 2 months of treatment, erythrocytes and plasma lutein concentrations increased in the Chlorella group but not in the placebo group. In the Chlorella-supplemented group, erythrocyte PLOOH concentrations after a total of 2 months of treatment were lower than the concentrations before supplementation. These results suggest that Chlorella ingestion improved erythrocyte antioxidant status and lowered PLOOH concentrations. These reductions might contribute to maintaining the normal function of erythrocytes and prevent the development of senile dementia.