Chemokines and chemokine receptors in arthritis.
Chemokines and chemokine receptors in arthritis.
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DOI：
10.2741/s53
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Koch AE
中科院分区：
文献类型：
--
作者：
Szekanecz Z;Vegvari A;Szabo Z;Koch AE
趋化因子参与白细胞向炎症部位的募集，例如类风湿性关节炎（RA）中的滑膜组织。趋化因子有结构和功能分类。前者包括CXC、CC、C和CX3C四类趋化因子。趋化因子也可以是炎症性的或稳态的，然而，这些功能经常重叠。抗趋化因子和抗趋化因子受体靶向治疗可能在未来的关节炎生物治疗中得到应用。该领域的大多数数据来自关节炎的动物模型，因为只有很少的人类RA试验已经完成。然而，很有可能开发出各种特异性趋化因子和趋化因子受体拮抗剂并用于RA患者。
Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.