Symptoms in pediatric asthmatics and air pollution: Differences in effects by symptom severity, anti-inflammatory medication use and particulate averaging time
Symptoms in pediatric asthmatics and air pollution: Differences in effects by symptom severity, anti-inflammatory medication use and particulate averaging time
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DOI：
10.2307/3434265
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发表时间：
1998-11-01
影响因子：
10.4
通讯作者：
Street, DH
中科院分区：
文献类型：
--
作者：
Delfino, RJ;Zeiger, RS;Street, DH
对人类和动物的实验研究表明，短期接触颗粒物会对呼吸系统产生不利影响，空气污染物，特别是臭氧，会产生促炎作用。然而，颗粒平均时间没有受到直接的科学评价，也缺乏流行病学研究来研究这个问题，以及是否会改变空气污染物的影响，哮喘严重程度和抗炎药物的使用存在差异。本研究探讨了不良哮喘症状（令人烦恼或干扰日常活动或睡眠）与O-3和颗粒物（120 ppb）的关系。纵向回归分析利用广义估计方程（GEE）模型控制自相关，一周中的一天，室外真菌和天气。哮喘症状与室外O-3和PM10在单一污染物和coregressions显着相关，1小时和8小时的最大PM10有较大的影响比24小时的平均值。亚组分析显示，当天PM10最大值的影响在10名更频繁出现症状（MS）的儿童中最强：1小时PM10从第90百分位数增加的不良症状的比值比（OR）为2.24 [95%置信区间（CI），1.46-3.46（47 μ g/m3）; 8小时PM10（36 μ g/m3）为1.82（CI，1.18-2.81）; 24小时PM10（25 μ g/m3）为1.50（CI，0.80-2.80）。亚组分析还显示，当天O-3的影响在14名不太频繁出现症状（LS）的儿童中最强：1小时O-3（58 ppb）的OR为2.15（CI，1.04-4.44），8小时O-3（46 ppb）的OR为1.92（CI，0.97-3.80）。两组均观察到24小时PM10的影响，尤其是5天移动平均值（MS和LS的OR分别为1.95和4.03; p
Experimental research in humans and animals points to the importance of adverse respiratory effects from short-term particle exposures and to the importance of proinflammatory effects of air pollutants, particularly O-3. However, particle averaging time has not been subjected to direct scientific evaluation, and there is a lack of epidemiological research examining both this issue and whether modification of air pollutant effects occurs with differences in asthma severity and anti-inflammatory medication use. The present study examined the relationship of adverse asthma symptoms (bothersome or interfered with daily activities or sleep) to O-3 and particles 120 ppb). Longitudinal regression analyses utilized the generalized estimating equations (GEE) model controlling for autocorrelation, day of week, outdoor fungi, and weather. Asthma symptoms were significantly associated with both outdoor O-3 and PM10 in single pollutant- and coregressions, with 1-hr and 8-hr maximum PM10 having larger effects than the 24-hr mean. Subgroup analyses showed effects of current day PM10 maximums were strongest in 10 more frequently symptomatic (MS) children: the odds ratios (ORs) for adverse symptoms from 90th percentile increases were 2.24 [95% confidence interval (CI), 1.46-3.46] for 1-hr PM10 (47 mu g/m(3)); 1.82 (CI, 1.18-2.81) for 8-hr PM10 (36 mu g/m(3)); and 1.50 (CI, 0.80-2.80) for 24-hr PM10 (25 mu g/m(3)). Subgroup analyses also showed the effect of current day O-3 was strongest in 14 less frequently symptomatic (LS) children: the ORs were 2.15 (CI, 1.04-4.44) for 1-hr O-3 (58 ppb) and 1.92 (CI, 0.97-3.80) for 8-hr O-3 (46 ppb). Effects of 24-hr PM10 were seen in both groups, particularly with 5-day moving averages (ORs were 1.95 for MS and 4.03 for LS; p