Ultrasonic stimulation of peripheral nervous tissue: an investigation into mechanisms
Ultrasonic stimulation of peripheral nervous tissue: an investigation into mechanisms
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DOI：
10.1088/1742-6596/581/1/012003
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Christopher J. Wright;J. C. Rothwell;Nader Saffari
中科院分区：
文献类型：
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作者：
Christopher J. Wright;J. C. Rothwell;Nader Saffari
神经刺激具有广泛的临床和研究潜力，但目前受到低分辨率、渗透性或高侵入性操作的限制。据先前的研究报道，与其他非侵入性方法相比，超声波能够以更高的分辨率引发神经刺激效应，但实现这一点的潜在机制以及如何实施的实际细节仍然知之甚少。当前的研究确定了该领域需要解决的主要问题，并提出了几种不同的方法来解决这些领域。在初步结果显示皮肤神经制剂成功刺激后，选择分离的体外周围神经束作为简单模型来演示和研究神经刺激效果。神经束的早期结果显示成功的神经刺激，表明周围神经轴突的结构对超声波敏感。使用该模型的进一步研究应该更准确地揭示哪些结构受到影响以及如何优化效果，有助于为体内应用中使用的未来程序和设备的设计提供信息。
Neuro-stimulation has wide ranging clinical and research potential but this is currently limited either by low resolution, penetration or by highly invasive procedures. It has been reported in previous studies that ultrasound is able to elicit a neuro-stimulatory effect at a higher resolution than other non-invasive approaches but both the underlying mechanism that makes this possible and the practical details of how it can be implemented are still poorly understood. The current study has identified the main issues that need to be resolved in the field, proposing several different approaches to tackling these areas. An isolated in vitro peripheral nerve bundle was chosen as a simple model to demonstrate and investigate the neuro-stimulatory effect after preliminary results showed successful stimulation in a skin-nerve preparation. Early results from the nerve bundle show successful neurostimulation, indicating that structures in the peripheral nerve axon are sensitive to ultrasound. Further research using this model should reveal more precisely what structures are being affected and how to optimise the effect, helping to inform the design of future procedures and devices used in in vivo applications.