Administration of GM1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in MPTP-treated mice.
Administration of GM1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in MPTP-treated mice.
复制标题
给予 GM1 神经节苷脂可消除 MPTP 治疗小鼠中抗精神病药物引起的感觉运动缺陷。
DOI：
10.1016/0304-3940(88)90062-6
复制
发表时间：
1988
影响因子：
2.5
通讯作者：
Neff,NH
中科院分区：
文献类型：
--
作者：
Weihmuller,FB;Hadjiconstantinou,M;Bruno,JP;Neff,NH
Injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and sensory neglect in MPTP-treated mice. GM1ganglioside treatment eliminates all of these behavioral impairments and also partially restores striatal dopamine content. These observations suggest that the MPTP-treated mouse may be a valuable model for studying mechanisms underlying parkinsonism and that administration of GM1ganglioside may be an effective therapy.
