Nested Case-Control Study of the Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae
Nested Case-Control Study of the Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae
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DOI：
10.1128/aac.00827-13
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发表时间：
2013-11-01
影响因子：
4.9
通讯作者：
Ruhe, Joerg J.
中科院分区：
文献类型：
--
作者：
Nigo, Masayuki;Cevallos, Catalina Salinas;Ruhe, Joerg J.
我们进行了一项巢式病例对照研究（比例为1:4），对最初出现替加环素敏感的MDRKP分离物的患者中出现的耐多药肺炎克雷伯菌（TR-MDRKP）分离物进行了研究。在260例患者中，24例（9%）在90天的随访期内，TR-MDRKP分离物临床培养呈阳性。在logistic回归分析中，接受替加环素（校正优势比[OR]， 5.06； 95%可信区间[CI]， 1.80 ~ 14.23; P = 0.002）是随后分离出TR菌株的唯一独立预测因子。
We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P = 0.002) was the only independent predictor of subsequent isolation of a TR strain.