Combined genome and proteome approach to identify new susceptibility genes.
Combined genome and proteome approach to identify new susceptibility genes.
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结合基因组和蛋白质组方法来识别新的易感基因。
DOI：
10.1002/ajmg.10344
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Karlsen,AllanE
中科院分区：
文献类型：
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作者：
Pociot,Flemming;Karlsen,AllanE
1 型糖尿病 (T1DM) 是一种多因素疾病，其特征是胰岛中产生胰岛素的 β 细胞发生特异性破坏。在发病过程中，免疫系统的细胞浸润胰岛，释放出对胰岛内的β细胞具有特异性毒性的细胞因子混合物。目标是了解导致这种特定 β 细胞毒性的分子机制，这将有助于设计新的 T1DM 干预策略。蛋白质组方法提供了细胞因子介导的β细胞破坏过程中β细胞蛋白表达模式变化的详细图片。将这种蛋白质组方法的信息与遗传学研究相结合，使我们相信有可能实现这一目标。 © 2002 Wiley-Liss, Inc.
Type 1 diabetes mellitus (T1DM) is a multifactorial disorder characterized by a specific destruction of the insulin‐producing beta cells in the islets of Langerhans. Cells from the immune system infiltrate the islet during the pathogenesis, releasing a mixture of cytokines demonstrated to be specifically toxic to the beta cells within the islets. The goal is to understand the molecular mechanisms responsible for this specific beta‐cell toxicity, which will allow the design of novel intervention strategies for T1DM. The proteome approach provides a detailed picture of the beta‐cell proteins changing expression pattern during cytokine‐mediated beta‐cell destruction. Combining the information from this proteome approach with genetic studies makes us believe that it is possible to reach this goal. © 2002 Wiley‐Liss, Inc.