Evidence for endogenous opioid release in the amygdala during positive emotion
Evidence for endogenous opioid release in the amygdala during positive emotion
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DOI：
10.1016/j.neuroimage.2008.08.032
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发表时间：
2009-01-01
期刊：
影响因子：
5.7
通讯作者：
Bench, C. J.
中科院分区：
文献类型：
--
作者：
Koepp, M. J.;Hammers, A.;Bench, C. J.
内源性阿片类药物释放与缓解厌恶情绪记忆有关，从而促进愉悦状态和随后对社会刺激的相互作用，从而形成社会偏好。然而，这一理论仍然存在争议。在健康志愿者中使用正电子发射断层扫描和[C-11]双丙诺啡(DPN)，我们发现与中性情绪相比，在积极情绪诱导期间，DPN与海马区阿片受体的结合显著减少。此外，积极情绪变化的大小与双侧杏仁核中DPN的结合呈负相关。我们发现DPN结合减少与内源性阿片类药物释放增加是一致的，这提供了直接证据，表明内源性阿片类药物的局部释放参与了人类积极情绪的调节。(C)2008 Elsevier Inc.保留所有权利。
Endogenous opioid release has been linked to relief from aversive emotional memories, thereby promoting a euphoric state and subsequent interactions towards social stimuli resulting in the formation of social preferences. However, this theory remains controversial. Using positron emission tomography and [C-11] diprenorphine (DPN) in healthy volunteers, we found significantly reduced DPN binding to opioid receptor in the hippocampus during positive mood induction compared to neutral mood. Furthermore, the magnitude of positive mood change correlated negatively with DPN binding in the amygdala bilaterally. Our finding of reduced DPN binding is consistent with increased release of endogenous opioids, providing direct evidence that localised release of endogenous opioids is involved in the regulation of positive emotion in humans. (C) 2008 Elsevier Inc. All rights reserved.