Neuroanatomical dissociation between bottom-up and top-down processes of visuospatial selective attention
Neuroanatomical dissociation between bottom-up and top-down processes of visuospatial selective attention
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DOI：
10.1016/j.neuroimage.2006.04.177
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发表时间：
2006-08-15
期刊：
影响因子：
5.7
通讯作者：
Stein, Elliot A.
中科院分区：
文献类型：
--
作者：
Hahn, Britta;Ross, Thomas J.;Stein, Elliot A.
将注意力资源分配到可用感觉输入的部分可以通过自下而上的过程来调节，即，对即将到来的刺激的自发定向（刺激驱动的注意力），以及自上而下的过程，即，有意识地，由知识、期望和目标驱动。本研究旨在通过采用一种范式，参数化地改变对这两个过程的要求，促进对大脑网络介导的自下而上和自上而下的视觉空间注意控制的理解。周边目标的空间可预测性参数变化的中央线索的一个，两个，三个或四个可能的位置。反应时随目标位置的有效提示的准确性增加而线性下降，随无效提示的准确性增加而线性上升。事件相关功能磁共振成像（fMRI）能够测量对线索和目标的血氧水平依赖（BOLD）反应。一个主要由左顶叶内沟，下和上级顶叶小叶，双侧楔前叶，额中回，包括上级额沟，和枕中回组成的左半球网络显示BOLD反应的线索，更精确的空间提示线性增加，表明自上而下的空间选择性注意的参与。与此相反，双侧颞顶交界处，扣带回，右中央前回和前，后额叶，双侧梭状回，舌回和核心显示BOLD响应的目标，增加了他们的空间不可预测性，表明参与刺激驱动的定向。结果表明，两个在很大程度上分离的神经网络介导了自上而下和自下而上的视觉空间选择性注意控制. (c)2006年爱思唯尔公司All rights reserved.
Allocation of attentional resources to portions of the available sensory input can be regulated by bottom-up processes, i.e., spontaneous orientation towards an oncoming stimulus (stimulus-driven attention), and by top-down processes, i.e., intentionally and driven by knowledge, expectation and goals. The present study aimed at advancing the understanding of brain networks mediating bottom-up and top-down control of visuospatial attention by employing a paradigm that parametrically varied demands on these two processes. Spatial predictability of peripheral targets was parametrically varied by centrally cueing one, two, three or four of four possible locations. Reaction time decreased linearly with more precise valid cueing of the target location and increased with more precise invalid cueing. Event-related functional magnetic resonance imaging (fMRI) enabled measurement of blood oxygenation level-dependent (BOLD) responses to cues and to targets. A mostly left-hemispheric network consisting of left intraparietal sulcus, inferior and superior parietal lobule, bilateral precuneus, middle frontal gyri including superior frontal sulci, and middle occipital gyri displayed BOLD responses to cues that increased linearly with more precise spatial cueing, indicating engagement by top-down spatial selective attention. In contrast, bilateral temporoparietal junction, cingulate gyrus, right precentral gyrus and anterior and posterior insula, bilateral fusiform gyri, lingual gyri and caucus displayed BOLD responses to targets that increased with their spatial unpredictability, indicating engagement by stimulus-driven orienting. The results suggest two largely dissociated neural networks mediating top - down and bottom - up control of visuospatial selective attention. (c) 2006 Elsevier Inc. All rights reserved.