Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.
Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.
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穗花果黄酮保护海马神经元：抗炎、抗氧化和抗凋亡作用
DOI：
10.4103/1673-5374.160109
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发表时间：
2015-07
影响因子：
6.1
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Zhang Z;Sun T;Niu JG;He ZQ;Liu Y;Wang F
阿门黄酮是一种天然的双黄酮化合物，具有许多生物学特性，包括抗炎、抗氧化和神经保护作用。我们推测阿门托黄酮在癫痫模型中具有神经保护作用。造模前，小鼠连续3天灌胃阿门托黄酮25 mg/kg。在小鼠点燃模型中，阿门托黄酮能有效预防匹罗卡品诱导的癫痫，抑制核因子-κB的激活和表达，抑制海马神经元的过度放电，减少癫痫发作，缩短发作时间，减少海马神经元的丢失和凋亡。结果提示，阿门托黄酮对癫痫小鼠海马神经元具有抗炎、抗氧化、抗凋亡的保护作用，从而有效预防癫痫发作的发生。
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.