Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies.
Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies.
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DOI：
10.1186/1476-069x-8-17
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发表时间：
2009-04-16
期刊：
影响因子：
--
通讯作者：
Forsberg B
中科院分区：
文献类型：
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作者：
Bråbäck L;Forsberg B
本综述的目的是评估近期前瞻性研究的证据，即长期交通污染可能导致儿童哮喘样症状和过敏性致敏的发展。我们回顾了自2002年以来发表的队列研究，并于2008年10月在PubMed上发现。总共有13篇基于9个队列数据的论文评估了交通暴露与呼吸系统健康之间的关系。所有调查都报告了与至少一些研究的呼吸道症状的相关性。然而，结果因儿童的年龄而异。然而，结果的一致性表明，交通废气有助于健康儿童呼吸道症状的发展。仅在四个欧洲出生队列中评估了交通尾气对过敏性致敏作用的潜在影响。长期暴露于室外空气污染物与挪威10岁学童的致敏性无关。相比之下，德国，荷兰和瑞典学龄前儿童有一个增加的风险敏感相关的交通废气，尽管相当类似的水平，在挪威的室外空气污染。与过敏相关的药物效应可能仅限于具有特定遗传多态性的个体。迄今为止，仅在瑞典出生队列的一个亚组中进行了致敏基因-环境相互作用的评估。需要进一步的遗传关联研究，并可能查明易受交通相关污染物不利影响的个人。未来的研究还应评估交通尾气对不同表型哮喘和喘息症状的发展和长期结局的影响。
The aim of this review was to assess the evidence from recent prospective studies that long-term traffic pollution could contribute to the development of asthma-like symptoms and allergic sensitization in children. We have reviewed cohort studies published since 2002 and found in PubMed in Oct 2008. In all, 13 papers based on data from 9 cohorts have evaluated the relationship between traffic exposure and respiratory health. All surveys reported associations with at least some of the studied respiratory symptoms. The outcome varied, however, according to the age of the child. Nevertheless, the consistency in the results indicates that traffic exhaust contributes to the development of respiratory symptoms in healthy children. Potential effects of traffic exhaust on the development of allergic sensitization were only assessed in the four European birth cohorts. Long-term exposure to outdoor air pollutants had no association with sensitization in ten-year-old schoolchildren in Norway. In contrast, German, Dutch and Swedish preschool children had an increased risk of sensitization related to traffic exhaust despite fairly similar levels of outdoor air pollution as in Norway. Traffic-related effects on sensitization could be restricted to individuals with a specific genetic polymorphism. Assessment of gene-environment interactions on sensitization has so far only been carried out in a subgroup of the Swedish birth cohort. Further genetic association studies are required and may identify individuals vulnerable to adverse effects from traffic-related pollutants. Future studies should also evaluate effects of traffic exhaust on the development and long term outcome of different phenotypes of asthma and wheezing symptoms.