Lower ratio of high-molecular-weight adiponectin level to total may be associated with coronary high-risk plaque.
Lower ratio of high-molecular-weight adiponectin level to total may be associated with coronary high-risk plaque.
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DOI：
10.1186/1756-0500-6-83
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发表时间：
2013-03-06
影响因子：
1.8
通讯作者：
Jesmin S
中科院分区：
文献类型：
--
作者：
Moroi M;Akter S;Nakazato R;Kunimasa T;Masai H;Furuhashi T;Fukuda H;Koda E;Sugi K;Jesmin S
虽然高分子量脂联素(HMW)被认为可以预防动脉粥样硬化，但HMW脂联素与冠状动脉斑块成分之间的关联尚不清楚。我们使用多层螺旋CT冠状动脉成像(MSCTCA)评估HMW/总脂联素比率是否与冠状动脉斑块的存在及其组成有关。对连续53例(71岁)MSCTCA冠状动脉狭窄50%的患者进行了血清总脂联素和HMW脂联素水平的测定。低密度冠状动脉斑块定义为平均CT密度为50 Hounsfield单位的斑块。多因素Logistic回归分析用于评估CT上存在低密度冠状动脉斑块的预测因素，低密度斑块被认为是高风险的。血清总脂联素和高分子脂联素水平降低与至少一个钙化或非钙化冠状动脉斑块的存在显著相关(总脂联素水平：优势比0.76，95%可信区间0.58~0.99，P = 0.048；高分子脂联素水平：优势比0.65，95%可信区间0.42~0.99，P = 0.047)。HMW/总脂联素比值低与冠状动脉低密度斑块的存在显著相关(4.551.94~21.90P = 0.049)。然而，无论是总脂联素还是高分子脂联素水平都与低密度冠状动脉斑块的存在无关。较低的总或高分子脂联素水平与钙化和非钙化冠状动脉斑块的存在有关，而高分子脂联素与总脂联素的比率较低与低密度冠状动脉斑块的存在(被认为是高风险)相关。测定总脂联素和高分子脂联素水平以及高分子脂联素与总脂联素的比值可能有助于冠状动脉斑块的危险分层。
Although high-molecular-weight (HMW) adiponectin is believed to protect against atherosclerosis, the association between HMW adiponectin and the composition of coronary plaques is unknown. We evaluated whether the HMW to total adiponectin ratio was associated with the presence of coronary plaque and its composition using multi-slice computed tomography coronary angiography (MSCTCA). Serum total and HMW adiponectin levels were measured in 53 consecutive patients (age, 71) with >50% coronary artery stenosis detected by MSCTCA. A low-attenuation coronary plaque was defined as a plaque with a mean CT density <50 Hounsfield units. Multivariate logistic regression analyses were performed to evaluate the predictors of the presence of low-attenuation coronary plaques, which is thought to be high risk, on CT. Decreased serum levels of total as well as HMW adiponectin were significantly associated with the presence of at least one calcified or non-calcified coronary artery plaque (total adiponectin level: odds ratio 0.76, 95% CI 0.58–0.99, P = 0.048; HMW adiponectin level: odds ratio 0.65, 95% CI 0.42–0.99, P = 0.047). A low ratio of HMW to total adiponectin was significantly associated with the presence of low-attenuation coronary plaques (4.55, 1.94–21.90, P = 0.049). However, neither the total adiponectin nor the HMW adiponectin level was associated with the presence of low-attenuation coronary plaques. Lower total or HMW adiponectin levels are associated with the presence of calcified and non-calcified coronary plaques, whereas a lower ratio of HMW to total adiponectin associated with the presence of low-attenuation coronary plaques (thought to be high risk). Measurement of total and HMW adiponectin levels and the HMW to total adiponectin ratio may be useful for risk stratification of coronary artery plaques.