Quantitative genetic analyses of postcanine morphological crown variation
Quantitative genetic analyses of postcanine morphological crown variation
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犬后形态冠变异的定量遗传分析
DOI：
10.1002/ajpa.23778
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发表时间：
2019
影响因子：
2.8
通讯作者：
Guatelli‐Steinberg, Debbie
中科院分区：
文献类型：
--
作者：
Stojanowski, Christopher M.;Paul, Kathleen S.;Seidel, Andrew C.;Duncan, William N.;Guatelli‐Steinberg, Debbie
目的本文介绍了对恒牙前磨牙、第一磨牙和第二磨牙的14个牙冠形态变异的狭义遗传力和双变量遗传相关的估计。我们的目标是告知数据收集和分析的做法，在牙科biodelance和提供洞察力的发展磨牙冠作为integrated structures.Materials and MethodsAfrican American dental casts从Menegaz‐Bock收集记录为亚利桑那州州立大学牙科人类学系统。使用SOLAR v.8.1.1生成狭义遗传力和遗传相关性的估计值，其中包括对年龄、性别和出生年份的评估作为协变量。连续规模和二分法估计provided.ResultsHeritability估计是不显着的大多数变量，但是，对于变量产生显着的估计，值是中等偏高的幅度和以前的研究相比。比较左侧和右侧的遗传力估计表明，在环境方差的表达中存在方向不对称性，这在前牙性状中是看不到的。遗传相关性中等antimeres和metameres和低的不同性状得分相同的牙冠。虽然注意到一些负相关，但很少达到统计学显著性。结果肯定了牙科生物距离中的一些当前数据清理和分析实践，但其他一些则受到质疑。这些措施包括汇集男性和女性，并结合左侧和右侧的数据到一个单一dataset.ConclusionsIn相比，前牙冠性状，postcanine遗传力往往是不显着的;然而，这些性状具有显着的遗传力也往往产生较高的估计。遗传相关性并不显著，部分原因是它们的动力不足。然而，M1的结果可能会提供深入了解基因，环境和发展之间的复杂关系，在确定最终冠的形式。
ObjectivesThis article presents estimates of narrow‐sense heritability and bivariate genetic correlation for 14 tooth crown morphological variants scored on permanent premolars, first molars, and second molars. The objective is to inform data collection and analytical practices in dental biodistance and to provide insights on the development of molar crowns as integrated structures.Materials and MethodsAfrican American dental casts from the Menegaz‐Bock collection were recorded for the Arizona State University Dental Anthropology System. Estimates of narrow‐sense heritability and genetic correlation were generated using SOLAR v.8.1.1, which included assessment of age, sex, and birth year as covariates. Both continuous scale and dichotomized estimates are provided.ResultsHeritability estimates were nonsignificant for the majority of variables; however, for variables yielding significant estimates, values were moderate to high in magnitude and comparable to previous studies. Comparing left and right‐side heritability estimates suggests directional asymmetry in the expression of environmental variance, something not seen in anterior tooth traits. Genetic correlations were moderate among antimeres and metameres and low for different traits scored on the same tooth crown. Although several negative correlations were noted, few reached statistical significance. Results affirm some of the current data cleaning and analytical practices in dental biodistance, but others are called into question. These include the pooling of males and females and combining left and right‐side data into a single dataset.ConclusionsIn comparison to anterior tooth crown traits, postcanine heritabilities were more often non‐significant; however, those traits with significant heritability also tended to produce higher estimates. Genetic correlations were unremarkable, in part, because they were underpowered. However, M1 results may provide insight into the complex relationship between genes, environment, and development in determining ultimate crown form.