Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading.
Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading.
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DOI：
10.1002/nbm.1940030407
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发表时间：
1990-08-01
影响因子：
2.9
通讯作者：
Feindel, W
中科院分区：
文献类型：
--
作者：
Arnold, D L;Shoubridge, E A;Feindel, W
我们获得了 11 个体内星形细胞瘤的局部水抑制质子磁共振谱。还从其中三个肿瘤中获得了局部磷光谱。所有肿瘤在手术、放疗或化疗前均经过检查。使用市售的 1.5 特斯拉组合成像和光谱系统进行检查，使用质子受激回波脉冲序列和磷 ISIS 脉冲序列。相对较高的乳酸共振强度与更恶性的组织学肿瘤分级和更具攻击性的行为相关。 N-乙酰天冬氨酸/肌酸的共振强度降低，胆碱/肌酸增加，但这些并不能可靠地区分肿瘤等级。有时会看到正常大脑光谱中不存在的其他未识别的共振。质子磁共振波谱提供了一种确定星形细胞瘤代谢行为的新方法，可能有助于对这些肿瘤患者的临床评估。
We have obtained localized, water-suppressed proton magnetic resonance spectra from eleven astrocytomas in vivo. Localized phosphorus spectra were also obtained from three of these tumors. All tumors were examined prior to surgery, radiotherapy or chemotherapy. Examinations were performed with a commercially available 1.5 Tesla combined imaging and spectroscopy system using a stimulated echo pulse sequence for protons and an ISIS pulse sequence for phosphorus. A relatively high lactate resonance intensity correlated with a more malignant histological tumor grade and more aggressive behaviour. The resonance intensity of N-acetylaspartate/creatine was decreased and choline/creatine was increased, but these did not reliably discriminate between tumor grades. Other unidentified resonances not present in spectra of normal brain were sometimes seen. Proton magnetic resonance spectroscopy provides a new method for determining the metabolic behaviour of astrocytomas that may be useful in the clinical assessment of patients with these tumors.