Japan Clinical Oncology Group (JCOG) prognostic index and characterization of long-term survivors of aggressive adult T-cell leukaemia-lymphoma (JCOG0902A)
Japan Clinical Oncology Group (JCOG) prognostic index and characterization of long-term survivors of aggressive adult T-cell leukaemia-lymphoma (JCOG0902A)
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DOI：
10.1111/bjh.12962
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发表时间：
2014-09-01
影响因子：
6.5
通讯作者：
Tsukasaki, Kunihiro
中科院分区：
文献类型：
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作者：
Fukushima, Takuya;Nomura, Shogo;Tsukasaki, Kunihiro
本研究评估了 3 项日本临床肿瘤学组 (JCOG) 试验中 276 名侵袭性成人 T 细胞白血病淋巴瘤 (ATL) 患者的临床特征。我们评估了存活超过 5 年的长期幸存者，并根据 Cox 回归分析获得的协变量构建了一个名为 JCOG-PI 的预后指数 (PI)。整个队列的中位生存时间（MST）为 11 个月。在 37 名存活超过 5 年的患者中，10 名淋巴瘤型患者没有观察到与疾病相关的死亡，而其他类型的患者中有 10 名与 ATL 相关的死亡。在 193 名患者的多变量分析中，基于校正的钙水平和体能状态的 JCOG-PI 确定了中危组和高危组，MST 分别为 14 个月和 8 个月（风险比为 1.926）。 JCOG-PI 在外部验证中是可重复的。存活超过 5 年的淋巴瘤型患者可能已被治愈。 JCOG-PI 对于识别预后极差的患者非常有价值，并将有助于设计未来结合新药或研究性治疗策略的试验。
This study evaluated the clinical features of 276 patients with aggressive adult T-cell leukaemia-lymphoma (ATL) in 3 Japan Clinical Oncology Group (JCOG) trials. We assessed the long-term survivors who survived >5 years and constructed a prognostic index (PI), named the JCOG-PI, based on covariates obtained by Cox regression analysis. The median survival time (MST) of the entire cohort was 11 months. In 37 patients who survived >5 years, no disease-related deaths in 10 patients with lymphomatype were observed in contrast to the 10 ATL-related deaths in other types. In multivariate analysis of 193 patients, the JCOG-PI based on corrected calcium levels and performance status identified moderate and high risk groups with an MST of 14 and 8 months respectively (hazard ratio, 1.926). The JCOG-PI was reproducible in an external validation. Patients with lymphoma- type who survived >5 years might have been cured. The JCOG-PI is valuable for identifying patients with extremely poor prognosis and will be useful for the design of future trials combining new drugs or investigational treatment strategies.