Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition.
Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition.
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DOI：
10.1080/15622975.2016.1190867
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发表时间：
2017-04
期刊：
影响因子：
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通讯作者：
Riederer P
中科院分区：
文献类型：
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作者：
Bandelow B;Baldwin D;Abelli M;Bolea-Alamanac B;Bourin M;Chamberlain SR;Cinosi E;Davies S;Domschke K;Fineberg N;Grünblatt E;Jarema M;Kim YK;Maron E;Masdrakis V;Mikova O;Nutt D;Pallanti S;Pini S;Ströhle A;Thibaut F;Vaghi MM;Won E;Wedekind D;Wichniak A;Woolley J;Zwanzger P;Riederer P
生物标志物被定义为特定于某些疾病或综合征的解剖学、生物化学或生理学特征。本文的目的是总结目前的知识，焦虑症，强迫症（OCD）和创伤后应激障碍（PTSD）的生物标志物。生物标志物研究的结果由该领域的国际专家组成的工作队进行了审查，该工作队由世界生物精神病学学会联合会生物标志物工作队和欧洲神经精神药理学焦虑症研究网络学院的成员组成。本文（第二部分）总结了在神经化学（神经递质，如血清素，去甲肾上腺素，多巴胺或GABA，神经肽，如胆囊收缩素，神经激肽，心钠素，催产素，HPA轴，神经营养因子，如NGF和BDNF，免疫学和CO2超敏反应），神经生理学（脑电图，心率变异性）和神经认知的潜在生物标志物的研究结果。随附的论文（第一部分）侧重于神经影像学和遗传学。虽然目前，没有一个假定的生物标志物是足够的和具体的诊断工具，丰富的高质量的研究已经积累，应该提高我们对焦虑症，强迫症和创伤后应激障碍的神经生物学原因的理解。
Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network. The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO2 hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics. Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.