Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability
Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability
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DOI：
10.1161/01.cir.99.7.855
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发表时间：
1999-02-23
期刊：
影响因子：
37.8
通讯作者：
Maseri, A
中科院分区：
文献类型：
--
作者：
Biasucci, LM;Liuzzo, G;Maseri, A
背景 - 在一组因不稳定型心绞痛入院的患者中，我们研究了出院时 C 反应蛋白 (CRP) 血浆水平是否持续升高，以及持续升高是否与不稳定复发相关。方法和结果 - 我们测量了 53 名因 Braunwald IIIB 不稳定型心绞痛入住我们冠心病监护室的患者的血浆 CRP、血清淀粉样 A 蛋白 (SAA)、纤维蛋白原、总胆固醇、幽门螺杆菌和肺炎衣原体抗体滴度。入院时、出院时和 3 个月后采集血样。对患者进行了为期一年的随访。出院时，49% 的患者 CRP 升高（>3 mg/L）；其中，42% 的人在入院时和 3 个月时水平升高。仅 15% 的患者出院时 CRP 水平达到水平
Background-In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability.Methods and Results-We measured plasma levels of CRP, serum amyloid A protein (SAA), fibrinogen, total cholesterol, and Helicobacter pylori and Chlamydia pneumoniae antibody titers in 53 patients admitted to our coronary care unit for Braunwald class IIIB unstable angina. Blood samples were taken on admission, at discharge, and after 3 months. Patients were followed for 1 year. At discharge, CRP was elevated (>3 mg/L) in 49% of patients; of these, 42% had elevated levels on admission and at 3 months. Only 15% of patients with discharge levels of CRP