Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
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DOI：
10.1016/j.cell.2020.09.038
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发表时间：
2020-11-12
期刊：
影响因子：
64.5
通讯作者：
Crotty, Shane
中科院分区：
文献类型：
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作者：
Moderbacher, Carolyn Rydyznski;Ramirez, Sydney, I;Crotty, Shane
关于抗原特异性免疫反应与COVID-19疾病严重程度之间的关系，目前的知识有限。我们在急性期和恢复期受试者的SARS-CoV-2特异性CD 4（+）和CD 8（+）T细胞水平以及中和抗体应答水平上完成了获得性免疫所有三个分支的联合检查。SARS-CoV-2特异性CD 4（+）和CD 8（+）T细胞分别与较轻的疾病相关。协调的SARS-CoV-2特异性适应性免疫应答与较轻的疾病相关，表明CD 4（+）和CD 8（+）T细胞在COVID-19的保护性免疫中发挥作用。值得注意的是，SARS-CoV-2抗原特异性反应的协调在65岁的个体中被破坏。幼稚T细胞的缺乏也与衰老和疾病预后不良有关。一个简单的解释是，协调的CD 4（+）T细胞，CD 8（+）T细胞和抗体反应是保护性的，但不协调的反应往往无法控制疾病，衰老和SARS-CoV-2的适应性免疫反应受损之间存在联系。
Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4(+) and CD8(+) T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4(+) and CD8(+) T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4(+) and CD8(+) T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals R 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that co-ordinated CD4(+) T cell, CD8(+) T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.