Elevated Serum Levels of Interleukin-15, Interleukin-16, and Human Chorionic Gonadotropin in Women With Preeclampsia
Elevated Serum Levels of Interleukin-15, Interleukin-16, and Human Chorionic Gonadotropin in Women With Preeclampsia
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DOI：
10.1016/s1701-2163(16)34098-1
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发表时间：
2009-02-01
影响因子：
1.8
通讯作者：
Makhlouf, Hanan H.
中科院分区：
文献类型：
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作者：
El-Baradie, Sahar M. Y.;Mahmoud, Manal;Makhlouf, Hanan H.
目的：本研究旨在探讨正常妊娠妇女和先兆子痫妇女血清白细胞介素15（IL-15）、白细胞介素16（IL-16）和人绒毛膜促性腺激素（β-hCG）水平之间的关系，以及它们与疾病严重程度的关系。我们还希望计算这些标志物在诊断疾病和预测其severity.Materials和方法的准确性：这项研究是在2006年12月和2007年9月之间在开罗法尤姆大学进行。选择32例拟行剖宫产术的先兆子痫孕妇（先兆子痫组），与35例血压正常的先兆子痫孕妇（对照组）进行年龄和妊娠时间的匹配。在先兆子痫的妇女中，18人患有重度先兆子痫，14人患有轻度先兆子痫。结果：子痫前期患者血清IL-15、IL-16和β-hCG水平均显著高于正常妊娠组（P < 0.001）;重度子痫前期患者的血清中TNF-α、IL-6、IL-10、IL-10水平明显高于轻度子痫前期患者（P < 0.001）。各组间血清IL-15、IL-16和β-hCG水平呈正相关。血清β-hCG预测子痫前期的敏感性、特异性、阳性预测值、阴性预测值和总准确性分别为56.25%、91.43%、85.71%、69.57%和74.63%。IL-15的这些值分别为94.44%、89.8%、77.27%、97.78%和91.04%，IL-16的这些值分别为88.89%、95.92%、88.89%、95.92%和94.03%。与正常血压妇女相比，先兆子痫妇女血清IL-15、IL-16和β-hCG水平显著升高，这些水平与疾病严重程度相关。然而，血清IL-15和IL-16在诊断重度先兆子痫方面的总体准确性高于β-hCG。
Objectives: We sought to investigate the relationship between serum levels of interleukin 15 (IL-15), interleukin 16 (IL-16), and human chorionic gonadotropin (beta-hCG) in women with a normal pregnancy and with preeclampsia, and their association with disease seventy. We also wished to calculate the accuracy of these markers in diagnosing the disease and predicting its severity.Materials and Methods: The study was conducted at Al Fayoum University in Cairo between December 2006 and September 2007. Thirty-two primigravid women with preeclampsia (preeclamptic group) scheduled for Caesarean Section were recruited and matched for age and duration of pregnancy with 35 normotensive primigravid women (control group). Of the preeclamptic women, 18 had severe preeclampsia, and 14 had mild preeclampsia. Blood sampling was performed for assays of serum IL-15, IL-16, and beta-hCG.Results: Serum concentrations of IL-15, IL-16, and beta-hCG were significantly greater in preeclamptic women than in normotensive pregnant women (P < 0.001). Moreover, they were significantly higher in women with severe preeclampsia than in mild cases (P < 0.001). There was a positive correlation between serum IL-15, IL-16, and beta-hCG among all groups. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of serum beta-hCG in predicting preeclampsia were 56.25%, 91.43%, 85.71%, 69.57%, and 74.63%, respectively. These values for IL-15 were 94.44%, 89.8%, 77.27%, 97.78%, and 91.04%, respectively, and for IL-16, the values were 88.89%, 95.92%, 88.89%, 95.92%, and 94.03%, respectively.Conclusion: Serum levels of IL-15, IL-16, and beta-hCG were significantly increased in preeclamptic women compared with normotensive women, and these levels correlated with disease seventy. However, serum IL-15 and 16 had a greater overall accuracy than beta-hCG in diagnosing severe preeclampsia.