Chiral CuxCoyS Nanoparticles under Magnetic Field and NIR Light to Eliminate Senescent Cells
Chiral CuxCoyS Nanoparticles under Magnetic Field and NIR Light to Eliminate Senescent Cells
复制标题
磁场和近红外光下的手性 CuxCoyS 纳米颗粒可消除衰老细胞
DOI：
10.1002/anie.202004575
复制
发表时间：
2020-06-04
影响因子：
16.6
通讯作者：
Kuang, Hua
中科院分区：
文献类型：
--
作者：
Li, Si;Sun, Maozhong;Kuang, Hua
在本研究中，手性CuxCoyS纳米颗粒（NPs）在交变磁场（AMF）和近红外（NIR）光子照射下选择性诱导衰老细胞凋亡。结果表明，d-CuxCoyS NPs的内化能力是l-NPs的2.5倍。在AMF和光子照射下，d-CuxCoyS NPs通过修饰β 2巨球蛋白（MG），在不损害正常细胞活性的情况下有效地消除衰老细胞。与单独应用NIR和AMF相比，由于光子诱导的细胞氧化还原和细胞骨架的机械损伤更为严重，它们的协同作用诱导caspase-3的产生时间更短，效率更高。此外，所开发的策略成功地用于去除体内衰老细胞。本研究开发了一种利用手性NPs调控细胞活性的可控方法，将为治疗疾病和促进健康提供有价值的途径。
In the present study, chiral CuxCoyS nanoparticles (NPs) were developed to selectively induce apoptosis of senescent cells using both an alternating magnetic field (AMF) and near infrared (NIR) photon illumination. The chiral effects on living cells were investigated, and d-CuxCoyS NPs showed about 2.5 times higher of internalized ability than l-NPs. By modifying beta 2 macroglobulin (MG), senescent cells were effectively eliminated by d-CuxCoyS NPs without damaging the activities of normal cells under AMF and photon illumination. Compared to the individual application of NIR illumination and AMF, their synergistic effect induced the production of caspase-3 with a much shorter treatment time and higher efficiency due to the more serious photon-induced cellular redox and mechanical damage of cellular skeleton. Moreover, the developed strategy was successfully used to remove senescent cells in vivo. This study developed a controllable way of regulating cell activities using chiral NPs, which will provide a valuable way for treating diseases and promoting health.