Development of the endocrine pancreas
Development of the endocrine pancreas
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DOI：
10.1016/s1262-3636(06)72807-5
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发表时间：
2006-12-01
影响因子：
7.2
通讯作者：
Gradwohl, G.
中科院分区：
文献类型：
--
作者：
Gradwohl, G.
本文简要综述了近年来在控制胰腺形态发生和分化的重要步骤、调控胰腺器官发生和胰岛细胞分化的转录因子以及参与β和α细胞谱系特化的转录因子等方面的研究进展。所有这些研究应该允许产生成熟和功能性β细胞所需的完整遗传程序的全面视图，因此，应该有助于指导未来1型糖尿病细胞替代疗法的策略。
This short review presents the recent breakthroughts in our understanding of the important steps controlling pancreas morphogenesis and differentiation, and on the transcription factors regulating pancreas organogenesis and islet cell differentiation and involved in the specification of the beta and alpha cell lineages. All these studies should permit a comprehensive view of the full genetic program necessary to produce mature and functional beta cells and thus, should be instrumental to guide future strategies for cell replacement therapies in type 1 diabetes.