AUTORADIOGRAPHIC LOCALIZATION OF OPIOID RECEPTORS IN VOCAL CONTROL REGIONS OF A MALE PASSERINE BIRD (JUNCO-HYEMALIS)
AUTORADIOGRAPHIC LOCALIZATION OF OPIOID RECEPTORS IN VOCAL CONTROL REGIONS OF A MALE PASSERINE BIRD (JUNCO-HYEMALIS)
复制标题
DOI：
10.1002/cne.903560308
复制
发表时间：
1995-06-05
影响因子：
2.5
通讯作者：
DEVICHE, P
中科院分区：
文献类型：
--
作者：
GULLEDGE, CC;DEVICHE, P
以往的研究已经发现鸟类发声控制区存在阿片肽样免疫反应，但这些区域是否含有阿片肽受体还没有得到研究。为解决这一问题，我们采用体外放射自显影技术，测定了成年雄性黑眼(Junco Hyemalis)发声控制区(X区、声带中心高位和丘间核团)的u阿片受体、β阿片受体和kappa阿片受体的分布和密度。为了评估这些区域的阿片受体密度是否取决于生殖系统的活动，我们还测量了春季、夏季和秋季收集的鸟类的这些密度。我们发现X区、更高的发声中枢和丘间核含有这三种受体类型，但阿片受体密度在这些区域中的任何一个都没有季节性变化。鸟类发声控制区存在特异性阿片受体，提示阿片类物质参与了发声行为的调控。这种参与可能包括短期(例如，听觉处理)和/或长期(例如，神经元可塑性)影响。(C)1995年Wiley-Liss公司
Previous studies have found opioid peptide-like immunoreactivity in avian vocal control regions, but whether these regions contain receptors for opioid peptides has not been examined. To address this question, we used quantitative in vitro autoradiography to determine the anatomical distribution and to measure the densities of mu, delta, and kappa opioid receptors in vocal control regions (area X, higher vocal center, and nucleus intercollicularis) of adult male dark-eyed juncos (Junco hyemalis). To evaluate whether opioid receptor densities in these regions depend on the activity of the reproductive system, we also measured these densities in birds collected during the spring, summer, and fall. We found area X, the higher vocal center, and nucleus intercollicularis to contain the three receptor types under study, but opioid receptor densities did not vary seasonally in any of these regions. The presence of specific opioid receptors in avian vocal control regions suggests the participation of opioids in the control of vocal behavior. This participation may consist of short-term (e.g., auditory processing) and/or long-term (e.g., neuronal plasticity) influences. (C) 1995 Wiley-Liss, Inc.