RNAi from plants to nematodes

RNAi from plants to nematodes
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DOI:
10.1016/j.tibtech.2007.01.007
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发表时间:
2007-03-01
影响因子:
17.3
通讯作者:
Vanholme, Bartel
Vanholme, Bartel
中科院分区:
工程技术1区
文献类型:
--
作者:
Gheysen, Godelieve;Vanholme, Bartel

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与2006年诺贝尔医学奖授予Fire和Mello以表彰他们发现RNAi的同时,植物科学家成功地使用基于RNAi的技术来控制线虫,这是一种迄今为止无法控制的植物寄生虫。最近的工作表明,在宿主植物中表达的双链RNA靶向管家或寄生基因的根结线虫导致对线虫感染的抗性。
Coincident with the award of the Nobel Prize for Medicine in 2006 to Fire and Mello for their discovery of RNAi, plant scientists have succeeded in using RNAi-based techniques to control nematodes, a hitherto unmanageable plant parasite. Recent work has demonstrated that the expression in a host plant of double-stranded RNA targeting housekeeping or parasitism genes in the root-knot nematode resulted in resistance to nematode infection.