Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis
Elevated serum creatinine and hyponatraemia as prognostic factors in canine acute pancreatitis
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DOI：
10.1111/avj.12638
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发表时间：
2017-11-01
影响因子：
1.1
通讯作者：
Pierini, A.
中科院分区：
文献类型：
--
作者：
Marchetti, V.;Gori, E.;Pierini, A.
目的根据临床和实验室资料，探讨影响犬急性胰腺炎（AP）预后的因素。设计2010年1月至2013年12月的回顾性研究。方法结合临床体征和异常SNAP (R) cPL （TM）检查结果，并结合提示胰腺炎的超声表现，诊断AP。狗被分为幸存者和非幸存者。我们评估了12个临床和实验室参数：呼吸频率、直肠温度、白细胞、红细胞压积、总血清蛋白、白蛋白、肌酐、胆固醇、总钙、钠和钾。对幸存者和非幸存者的临床和临床病理资料进行统计学比较。P < 0.05被认为是显著的和P < 0.01为极显著。计算比值比（OR）。结果该研究纳入了50只诊断为AP的客户拥有的狗。血清肌酐（P = 0.017）和钠（P = 0.004）与结果显著相关。血清钠< 139.0 mmol/L （139.0 mEq/L）、血清肌酐bb0 < 212 mu mol/L （2.4 mg/dL）与预后不良显著相关。氮血症（OR 12.5； 95%可信区间（CI） 1.32-118.48）和低钠血症（OR 4.9; 95% CI 1.36-17.64）与死亡风险增加相关。结论：在AP犬中，低钠血症和氮血症似乎与死亡风险增加显著相关。
Objective To evaluate prognostic factors for canine acute pancreatitis (AP) based on clinical and laboratory data that can be easily assessed in veterinary practice.Design Retrospective study between January 2010 and December 2013.Methods The diagnosis of AP was based on clinical signs and an abnormal SNAP (R) cPL (TM) test result, concurrently with an ultrasound pattern suggestive of pancreatitis. Dogs were divided into survivors and non-survivors. We evaluated 12 clinical and laboratory parameters: respiratory rate, rectal temperature, white blood cells, haematocrit, total serum proteins, albumin, creatinine, cholesterol, total and ionised calcium, sodium and potassium. Clinical and clinicopathological data were statistically compared between survivors and non-survivors. A value of P < 0.05 was considered significant and P < 0.01 as highly significant. The odds ratio (OR) was calculated.Results The study enrolled 50 client-owned dogs with a diagnosis of AP. Serum creatinine (P = 0.017) and sodium (P = 0.004) correlated significantly with the outcome. Serum sodium < 139.0 mmol/L (139.0 mEq/L) and serum creatinine > 212 mu mol/L (2.4 mg/dL) were associated significantly with poor prognosis. Azotaemia (OR 12.5; 95% confidence interval (CI) 1.32-118.48) and hyponatraemia (OR 4.9; 95% CI 1.36-17.64) were associated with increased risk of death.Conclusions In dogs with AP, hyponatraemia and azotaemia seem to be significantly associated with an increased risk of death.