REVISITING THE ODDBALL PARADIGM - NONTARGET VS NEUTRAL STIMULI AND THE EVALUATION OF ERP ATTENTIONAL EFFECTS
REVISITING THE ODDBALL PARADIGM - NONTARGET VS NEUTRAL STIMULI AND THE EVALUATION OF ERP ATTENTIONAL EFFECTS
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DOI：
10.1016/0028-3932(92)90042-k
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发表时间：
1992-08-01
期刊：
影响因子：
2.6
通讯作者：
MAUGUIERE, F
中科院分区：
文献类型：
--
作者：
GARCIALARREA, L;LUKASZEWICZ, AC;MAUGUIERE, F
我们记录了在没有任何认知任务（“中性条件”）的情况下传递的同质音调的听觉诱发电位（AEPs）的地形图，并将其与在古怪范式中作为非目标时对相同刺激的反应进行了比较。相对于中性条件，非目标反应表现出N100振幅的增加，这取决于两种不同但部分重叠的效应。“早期效应”具有与外源性N100相似的潜伏期和地形，可能反映了整体警觉性状态的变化，因为其振幅在测试结束时下降。“后期效应”影响了n100的下降斜率，并具有与加工负性一致的特征。其前缘分布，地形图显示右侧优势。最后，非目标反应表现出中心阳性（P250），这在中性aep中没有出现。P250具有几个特征，包括潜伏期、振幅和头皮地形，内源性ERP成分通常被标记为“P3a”。非目标P250可能是注意力向刺激转移的结果，反映了分类过程的某些方面。我们建议，简单古怪范式的非目标反应应与目标反应一起进行常规研究，以提高认知内啡反应的诊断能力。值得注意的是，非目标反应可能有助于确定异常的目标- p300是否与注意力资源动员缺陷有关。
We recorded topographic mapping of auditory evoked potentials (AEPs) to homogeneous series of tones delivered in the absence of any cognitive task ("neutral condition") and compared them with responses to identical stimuli when they acted as non-targets in an oddball paradigm. With respect to the neutral condition, non-target responses showed an increase in N100 amplitude which was found to depend on two different, but partially overlapping effects. The "early effect" had similar latency and topography as exogenous N100 and may reflect changes in the overall state of alertness since its amplitude declined at the end of the test. The "late effect" affected the N100s descending slope and had features consistent with those of a processing negativity. It was frontally distributed, and topographic mapping revealed a right-sided predominance. Finally, non-target responses exhibited a central positivity (P250) which did not appear in neutral AEPs. P250 shares several features, including latency, amplitude and scalp topography, with the endogenous ERP component commonly labelled "P3a". Non-target P250 could be the result of an attentional shift towards the stimuli, and reflect some aspects of the classification process. We suggest that non-target responses in simple oddball paradigms should be routinely studied along with target responses in order to improve the diagnostic capabilities of cognitive ER Ps. Notably, non-target responses may help to decide whether an abnormal target-P300 is related or not to a deficit in the mobilization of attentional resources.