Feeding response to melanocortin agonist predicts preference for and obesity from a high-fat diet
Feeding response to melanocortin agonist predicts preference for and obesity from a high-fat diet
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DOI：
10.1016/j.physbeh.2005.04.011
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发表时间：
2005-06-02
影响因子：
2.9
通讯作者：
Boggiano, MM
中科院分区：
文献类型：
--
作者：
Chandler, PC;Viana, JB;Boggiano, MM
过度消费和增加高脂肪（HF）食物的选择有助于普通肥胖症的发展。由于下丘脑黑皮质素（MC）系统在调节食物摄入和饮食选择中起着不可或缺的作用，我们测试了这一假设，即饮食诱导的肥胖（DIO）的倾向（-P）或阻力（-R）可能是由于MC功能的差异。我们发现，在发展肥胖症，而仍然保持对食物，急性，中央管理MTII，MC激动剂，产生了更大的厌食反应在DIO-P大鼠比在DIO-R大鼠。然而，在仅5天的专门HF喂养后，DIO-R大鼠在MTII治疗后的摄入抑制显著大于维持食物时的摄入抑制。此外，在HF饮食仅5天后，DIO-P大鼠对MTII治疗的反应比DIO-R大鼠低得多。事实上，MTII诱导的厌食症在HF喂养与体重增加的HF饮食呈负相关。这些结果表明，在DIO-R大鼠中HF进食的自愿减少可能是由增加的内源性MC信号传导介导的，该信号可能在DIO-P大鼠中受损。MC调节的差异也可以解释在DIO-P大鼠中观察到的对HF而不是低脂肪食物选择的偏好。最后，结果表明对外源性MC挑战的反应可用于预测对DIO的倾向性或抵抗性。(c)2005年爱思唯尔公司All rights reserved.
Overconsumption and increased selection of high fat (HF) foods contribute to the development of common obesity. Because the hypothalamic melanocortin (MC) system plays an integral role in the regulation of food intake and dietary choice, we tested the hypothesis that proneness (-P) or resistance (-R) to dietary-induced obesity (DIO) may be due to differences in MC function. We found that prior to developing obesity and while still maintained on chow, acute, central administration of MTII, an MC agonist, produced a greater anorectic response in DIO-P rats than in DIO-R rats. However, after only 5 days of exclusive HF feeding, the DIO-R rats had significantly greater suppression of intake after MTII treatment than they did when maintained on chow. In addition, the DIO-P rats were much less responsive to MTII treatment than the DIO-R rats after only 5 days of the HF diet. In fact, MTII-induced anorexia during HF feeding correlated negatively with body weight gained on the HF diet. These results suggest that the voluntary decrease of HF feeding in DIO-R rats may be mediated by increased endogenous MC signaling, a signal likely compromised in DIO-P rats. Differences in MC regulation may also explain the observed preference for HF over a lower fat food choice in DIO-P rats. Finally, the results indicate that responses to exogenous MC challenge can be used to predict proneness or resistance to DIO. (c) 2005 Elsevier Inc. All rights reserved.