Alignment of systematic reviews published in the Cochrane Database of Systematic Reviews and the Database of Abstracts and Reviews of Effectiveness with global burden-of-disease data: a bibliographic analysis.
Alignment of systematic reviews published in the Cochrane Database of Systematic Reviews and the Database of Abstracts and Reviews of Effectiveness with global burden-of-disease data: a bibliographic analysis.
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将 Cochrane 系统评价数据库和有效性摘要和评价数据库中发表的系统评价与全球疾病负担数据进行调整：书目分析。
DOI：
10.1136/jech-2014-205389
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发表时间：
2015
影响因子：
6.3
通讯作者：
Wolfenden,Luke
中科院分区：
文献类型：
--
作者：
Yoong,SzeLin;Hall,Alix;Williams,ChristopherM;Skelton,Eliza;Oldmeadow,Christopher;Wiggers,John;Karimkhani,Chante;Boyers,LindsayN;Dellavalle,RobertP;Hilton,John;Wolfenden,Luke
背景对高质量证据的系统审查用于为政策和实践提供信息。为了改善社区健康，这种审查的产生应该与疾病负担相一致。本研究旨在评估系统评价的研究产出是否与疾病负担成比例地一致，该评价使用死亡率和伤残调整寿命年(DALY)的百分比来评估。方法对Cochrane系统评价数据库(CDSR)和效果评价摘要数据库(DARE)2012年1月至2013年8月发表的综述进行横断面审计。死亡率和DALYs的百分比来自2010年全球疾病负担研究。根据死亡率和DALY的百分比计算标准化残差(SRD)，其中SRD大于或小于3分别被视为过度研究或未充分研究。结果来自CDSR的1029篇综述和DARE的1928篇综述被审查。在CDSR和DARE数据库中发表的系统综述与DALY百分比之间存在显著相关性(CDSR：r=0.68，p=0.001；DARE：r=0.6，p<；0.001)。两个数据库发表的系统综述数与死亡率之间无显著相关性(CDSR：r=0.34，p=0.14；DARE：r=0.22，p=0.34)。相对于死亡率，对精神和行为障碍、肌肉骨骼疾病和其他非传染性疾病进行了过度研究。CDSR中孕产妇疾病与死亡率和DALYs的相关性研究过多。结论系统评价的重点与DALYs有中度相关性。相对于死亡率，特别是在健康和医学审查的背景下，可能会过度研究一些情况。
BackgroundSystematic reviews of high-quality evidence are used to inform policy and practice. To improve community health, the production of such reviews should align with burden of disease. This study aims to assess if the volume of research output from systematic reviews proportionally aligns with burden of disease assessed using percentages of mortality and disability-adjusted life years (DALYs).MethodsA cross-sectional audit of reviews published between January 2012 and August 2013 in the Cochrane Database of Systematic Reviews (CDSR) and Database of Abstracts of Reviews of Effects (DARE) was undertaken. Percentages of mortality and DALYs were obtained from the 2010 Global Burden of Disease study. Standardised residual differences (SRD) based on percentages of mortality and DALYs were calculated, where conditions with SRD of more than or less than three were considered overstudied or understudied, respectively.Results1029 reviews from CDSR and 1928 reviews from DARE were examined. There was a significant correlation between percentage DALYs and systematic reviews published in CDSR and DARE databases (CDSR: r=0.68, p=0.001; DARE: r=0.60, p<0.001). There was no significant correlation between percentage mortality and number of systematic reviews published in either database (CDSR: r=0.34, p=0.14; DARE: r=0.22, p=0.34). Relative to percentage of mortality, mental and behavioural disorders, musculoskeletal conditions and other non-communicable diseases were overstudied. Maternal disorders were overstudied relative to percentages of mortality and DALYs in CDSR.ConclusionsThe focus of systematic reviews is moderately correlated with DALYs. A number of conditions may be overstudied relative to percentage of mortality particularly in the context of health and medical reviews.