X-ray diffraction and SEM study of kidney stones in Israel: quantitative analysis, crystallite size determination, and statistical characterization
X-ray diffraction and SEM study of kidney stones in Israel: quantitative analysis, crystallite size determination, and statistical characterization
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以色列肾结石的 X 射线衍射和 SEM 研究：定量分析、微晶尺寸测定和统计表征
DOI：
10.1007/s10653-011-9374-6
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发表时间：
2011
影响因子：
4.2
通讯作者：
M. Duvdevani
中科院分区：
文献类型：
--
作者：
V. Uvarov;I. Popov;N. Shapur;Tamer Abdin;O. Gofrit;D. Pode;M. Duvdevani
泌尿系统结石已被公认为最痛苦的医疗疾病之一。对结石的相组成的可靠了解对于阐明结石病的潜在病因是非常重要的。我们在这里报告的结果进行定量X射线衍射相位分析278肾结石的275例患者在哈大沙希伯来大学医院（耶路撒冷，以色列）泌尿科治疗。采用归一化参考强度比法对多组分样品中的生物矿物进行定量。根据观察到的物相组成，所有测试的石头可分为五个化学组：草酸盐（43.2%）、磷酸盐（7.7%）、尿酸盐（10.3%）、胱氨酸（2.9%）和由不同矿物混合物组成的石头（35.9%）。沿着了每个分配的化学基团的详细分析以及所有观察到的结晶相的晶粒尺寸计算。所获得的结果进行了比较，与来自不同地理区域的已公布的数据。用扫描电子显微镜（SEM）和能谱仪（EDS）研究了肾结石中相的形态和空间分布。这种对肾结石的相组成和结构特征的详细研究首次在以色列进行。
Urinary calculi have been recognized as one of the most painful medical disorders. Tenable knowledge of the phase composition of the stones is very important to elucidate an underlying etiology of the stone disease. We report here the results of quantitative X-ray diffraction phase analysis performed on 278 kidney stones from the 275 patients treated at the Department of Urology of Hadassah Hebrew University Hospital (Jerusalem, Israel). Quantification of biominerals in multicomponent samples was performed using the normalized reference intensity ratio method. According to the observed phase compositions, all the tested stones were classified into five chemical groups: oxalates (43.2%), phosphates (7.7%), urates (10.3%), cystines (2.9%), and stones composed of a mixture of different minerals (35.9%). A detailed analysis of each allocated chemical group is presented along with the crystallite size calculations for all the observed crystalline phases. The obtained results have been compared with the published data originated from different geographical regions. Morphology and spatial distribution of the phases identified in the kidney stones were studied with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). This type of detailed study of phase composition and structural characteristics of the kidney stones was performed in Israel for the first time.