Stimulant actions in rodents: Implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse
Stimulant actions in rodents: Implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse
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DOI：
10.1016/j.biopsych.2004.12.036
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发表时间：
2005-06-01
影响因子：
10.6
通讯作者：
Segal, DS
中科院分区：
文献类型：
--
作者：
Kuczenski, R;Segal, DS
大多数证据支持继续使用兴奋剂作为治疗儿童注意力缺陷/多动障碍（ADHD）的最佳药物疗法，但对长期服用兴奋剂可能造成的持久行为和神经适应性后果知之甚少。尽管各种临床前研究，特别是那些使用哌醋甲酯（MP）的研究，试图解决这些问题，但大多数研究使用的程序可能不能充分模拟临床治疗条件，结果也不完全一致。特别是，选择模拟临床暴露的MP剂量的基本原理尚未得到很好的定义。我们建议使用更合适的治疗条件，包括使血浆药物水平与治疗水平相当的剂量，将为充分评估兴奋剂心理治疗治疗ADHD的治疗机制和潜在的长期后果提供更准确的模型。
Most evidence supports the continued use of stimulants as the best available pharmacotherapy the treatment of children with attention-deficit/hyperactivity disorder (ADHD), but little is known about possible enduring behavioral and neuroadaptational consequences of long-term stimulant exposure. Although a variety of preclinical studies, particularly, those using methylphenidate (MP), have attempted to address these issues, most of these studies have used procedures that might not adequately simulate clinical treatment conditions, and results have not been entirely consistent. In particular, the rationale for selection of MP doses that simulate clinical exposure has not been well defined. We suggest that the use of more appropriate treatment conditions, including doses that result in plasma drug levels comparable to therapeutic levels, will provide a more accurate model for adequately assessing the therapeutic mechanisms and potential long-term consequences of stimulant psychotherapy in the treatment of ADHD.