Prion genotypes in Central America suggest selection for the V129 allele.
Prion genotypes in Central America suggest selection for the V129 allele.
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中美洲的朊病毒基因型表明选择 V129 等位基因。
DOI：
10.1002/ajmg.b.30248
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Singleton,Andrew
中科院分区：
文献类型：
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作者：
Hardy,John;Scholz,Sonja;Evans,Whitney;Goldfarb,Lev;Singleton,Andrew
通过充分表征的人类多样性样本系列，我们发现V129朊病毒等位基因在南美人群中的频率相对于其起源的东亚人群非常高。我们认为朊病毒位点存在选择，可能是由库鲁样疾病介导的，这影响了它的等位基因频率。©2005 Wiley‐Liss, Inc。
Using the well‐characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru‐like diseases, which has influenced its allele frequency. © 2005 Wiley‐Liss, Inc.