Hepatitis C virus inhibitory hydrolysable tannins from the fruits of Terminalia chebula
Hepatitis C virus inhibitory hydrolysable tannins from the fruits of Terminalia chebula
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榄仁树果实中的丙型肝炎病毒抑制性水解单宁
DOI：
10.1016/j.fitote.2014.09.014
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发表时间：
2014-12-01
期刊：
影响因子：
3.4
通讯作者：
Ma, Chao-Mei
中科院分区：
文献类型：
--
作者：
Ajala, Olusegun S.;Jukov, Azzaya;Ma, Chao-Mei
从诃子果实中分得两个新的水解单宁类化合物，即车步梅宁A（1）和车步梅宁B（2），以及8个已知的相关化合物（3-10）。新化合物的结构通过光谱数据分析确定，已知化合物的结构通过将其光谱数据与文献值进行比较来表征。通过HCV蛋白酶抑制试验对所有分离株进行评价，发现一些化合物具有潜在活性。(C)2014爱思唯尔有限公司版权所有。
Two new hydrolysable tannins, chebumeinin A (1) and chebumeinin B (2), together with eight known related compounds (3-10), were isolated from the fruits of Terminalia chebula. The new compounds were structurally determined by analysis of their spectroscopic data and the known compounds characterized by comparing their spectroscopic data with literature values. All isolates were evaluated by an HCV protease inhibition assay, and some compounds were found to be potently active. (C) 2014 Elsevier B.V. All rights reserved.