Relationship between CO and transit times for dye and thermal indicators in central circulation.
Relationship between CO and transit times for dye and thermal indicators in central circulation.
复制标题
CO 与中央循环中染料和热指示剂的通过时间之间的关系。
DOI：
10.1152/jappl.1986.60.4.1363
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Gray,BA
中科院分区：
文献类型：
--
作者：
Carlile,PV;Beckett,RC;Gray,BA
我们研究了可能影响热染料双指示剂稀释法估算肺水的两个因素：1）心输出量（CO）的变化，以及2）与心脏组织的热平衡。理论上，热指示剂和染料指示剂的平均通过时间之间的差异（Δ MTT）与热指示剂的血管外分布容积（VODev）成正比，与CO成反比。由于测量仪器的响应时间差异，Δ MTT还包括时间元素DT，因此Δ MTT = VODev/CO + DT。在9只麻醉犬上，记录了左心房（LA）和右心房（RA）注射异丙肾上腺素（Isoproterenol）后CO从2.35 ml × s ~（-1）增加到6.65 ml × kg ~（-1）时的主动脉热曲线和染料曲线，并进行了Δ MTT对CO ~（-1）的回归。在体外测量DT以与y轴截距进行比较。在9只犬中的6只中，LA注射的回归斜率与零无差异，表明心脏组织中的热指示剂没有可测量的分布容积。对于RA注射，在所有实验中Δ MTT和CO-1之间的关系是线性的，平均相关系数为0.97 +/- 0.01（SE），表明在CO增加三倍时VODev是恒定的。尽管DT的体外测量与回归的y轴截距的平均值非常一致，DT的小的受试者之间的差异可以导致以常规方式使用DT的体外估计计算的血管外热容量的明显的与流动相关的变化。
We investigated two factors that may influence the estimation of lung water by the thermal-dye double-indicator-dilution method: 1) changes in cardiac output (CO), and 2) thermal equilibration with cardiac tissue. In theory, the difference between mean transit times of thermal and dye indicators (delta MTT) is proportional to the extravascular volume of distribution of the thermal indicator (VODev) and inversely related to CO. The delta MTT also includes a time element DT due to the difference in response times of the measuring instruments such that delta MTT = VODev/CO + DT. In nine anesthetized dogs we recorded 286 aortic thermal and dye curves following left atrial (LA) and right atrial (RA) injections as CO was increased from 2.35 to 6.65 ml X s-1 X kg-1 by isoproterenol infusion, and a regression of delta MTT on CO-1 was performed. DT was measured in vitro for comparison with the y-intercept. In six of nine dogs the slope of the regression for LA injections was not different from zero, indicating that there is no measurable volume of distribution for thermal indicator in cardiac tissue. For RA injections the relationship between delta MTT and CO-1 was linear in all experiments, with an average correlation coefficient of 0.97 +/- 0.01 (SE), indicating that the VODev was constant over a threefold increase in CO. Although the in vitro measurement of DT agreed closely with the average of the y-intercepts of the regressions, small between-subject differences in DT can lead to apparent flow-related changes in extravascular thermal volume computed in the conventional fashion using the in vitro estimate of DT.