Family-based association study of the arsenite methyltransferase gene (AS3MT, rs11191454) in Korean children with attention-deficit hyperactivity disorder
Family-based association study of the arsenite methyltransferase gene (AS3MT, rs11191454) in Korean children with attention-deficit hyperactivity disorder
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DOI：
10.1097/ypg.0000000000000064
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发表时间：
2015-02
影响因子：
0.9
通讯作者：
Subin Park;Jong-Eun Park;H. Yoo;Jae-Won Kim;Soo-Churl Cho;M. Shin;J. Cheong;D. Han;Bung-Nyun Kim-Bun
中科院分区：
文献类型：
--
作者：
Subin Park;Jong-Eun Park;H. Yoo;Jae-Won Kim;Soo-Churl Cho;M. Shin;J. Cheong;D. Han;Bung-Nyun Kim-Bun
我们检查了两个候选基因（亚砷酸甲基转移酶基因（AS3MT，rs11191454）和间胰蛋白酶抑制剂重链 3 基因（ITIH3，rs2535629））中选定的多态性与韩国人群中注意力缺陷多动障碍（ADHD）之间的关联。总共招募了 238 名 ADHD 患者及其亲生父母。孩子们接受了智商测试，而他们的父母则完成了儿童行为检查表。在181个三人组的传递不平衡测试中，我们发现ADHD儿童AS3MT rs11191454多态性处的A等位基因过度传递（2=8.81，P=0.003）。然而，ITIH3 rs52535629 多态性没有优先传递（2=0.14，P=0.707）。我们的结果为 ADHD 中 AS3MT rs11191454 多态性的 A 等位基因过度传递提供了初步证据。
We examined the association between the selected polymorphisms in two candidate genes, the arsenite methyltransferase gene (AS3MT, rs11191454) and the inter--trypsin inhibitors heavy chain-3 gene (ITIH3, rs2535629), and attention-deficit hyperactivity disorder (ADHD) in a Korean population. A total of 238 patients with ADHD, along with both of their biological parents, were recruited. The children were administered intelligence quotient tests, whereas their parents completed the Child Behavior Checklist. In the transmission disequilibrium test on 181 trios, we found overtransmission of the A allele at the AS3MT rs11191454 polymorphism in children with ADHD (2=8.81, P=0.003). However, there was no preferential transmission at the ITIH3 rs52535629 polymorphism (2=0.14, P=0.707). Our results provide preliminary evidence for the overtransmission of the A allele at the AS3MT rs11191454 polymorphism in ADHD.