The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer.
The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer.
复制标题
基质金属蛋白酶及其在结直肠癌中的抑制剂的行为。
DOI：
10.3390/ijms131013240
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发表时间：
2012-10-16
影响因子：
5.6
通讯作者：
Tulassay Z
中科院分区：
文献类型：
--
作者：
Herszényi L;Hritz I;Lakatos G;Varga MZ;Tulassay Z
基质金属蛋白酶（MMPs）在肿瘤生长、侵袭和转移的细胞外基质成分的降解中发挥重要作用。MMPs由天然抑制剂控制，称为金属蛋白酶组织抑制剂（TIMPs）。我们和其他人已经证明MMPs和TIMPs在结直肠癌（CRC）的肿瘤侵袭、进展和转移过程中尤为重要。MMPs和TIMPs可能不仅参与肿瘤的侵袭和转移，还参与结直肠腺瘤的癌变。最近的一些研究表明，术前血清或血浆MMP-2、MMP-9和TIMP-1抗原水平高是CRC患者预后不良的重要预测因素，其测定可能有助于识别癌症复发风险较高的患者。MMP-9和TIMP-1在结直肠癌中具有显著的潜在肿瘤标志物作用。其诊断敏感性始终高于传统的生物标志物。通过开发对某些MMPs具有高度特异性的新一代MMPs选择性抑制剂来靶向结直肠癌，是未来一个充满希望和挑战的领域。
Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled by natural inhibitors called tissue inhibitors of metalloproteinases (TIMPs). We and others have demonstrated that MMPs and TIMPs are especially important in the process of tumor invasion, progression and the metastasis of colorectal cancer (CRC). It has been proposed that MMPs and TIMPs might play a part not only in tumor invasion and initiation of metastasis but also in carcinogenesis from colorectal adenomas. Several recent studies demonstrated that high preoperative serum or plasma MMP-2, MMP-9 and TIMP-1 antigen levels are strong predictive factors for poor prognosis in patients with CRC and their determination might be useful for identification of patients with higher risk for cancer recurrence. MMP-9 and TIMP-1 have significant potential tumor marker impact in CRC. Their diagnostic sensitivity is consistently higher than those of conventional biomarkers. The pharmacological targeting of CRC by the development of a new generation of selective inhibitors of MMPs, that is highly specific for certain MMPs, is a promising and challenging area for the future.
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影响因子：
3.7
作者：
Cavallo-Medved D;Rudy D;Blum G;Bogyo M;Caglic D;Sloane BF
通讯作者：
Sloane BF
影响因子：
50.3
作者：
Bromberg J;Wang TC
通讯作者：
Wang TC
影响因子：
5.8
作者：
Burney, Basil O.;Hayes, Teresa G.;Garcia, Jose M.
通讯作者：
Garcia, Jose M.
影响因子：
6
作者：
Bourboulia, Dimitra;Jensen-Taubman, Sandra;Stetler-Stevenson, William G.
通讯作者：
Stetler-Stevenson, William G.
影响因子：
4.8
作者：
Cattaneo, M;Fontanella, E;Biunno, I
通讯作者：
Biunno, I