Effects of C-reactive protein on platelet function. I. Inhibition of platelet aggregation and release reactions.
Effects of C-reactive protein on platelet function. I. Inhibition of platelet aggregation and release reactions.
复制标题
C反应蛋白对血小板功能的影响。
作者：
B. Fiedel;H. Gewurz
C-反应蛋白(CRP)是一种急性时相反应物，与免疫球蛋白具有许多共同的功能特征。在目前的研究中，发现CRP可以抑制改良的人免疫球蛋白或凝血酶刺激的人血小板聚集。这种作用不涉及钙离子的螯合或细胞毒性，并被更大数量的聚集剂所克服。C反应蛋白也能抑制血小板因子3的活化，但不能抑制β-葡萄糖醛酸酶的释放。因此，CRP可以抑制多种血小板的反应性。我们认为，在炎症反应、防御反应和修复反应中，CRP的这一特性可能在控制血小板反应性方面发挥重要作用。
C-reactive protein (CRP) is an acute phase reactant which shares numerous functional characteristics with the immunoglobulins. In the present study CRP was found to inhibit the aggregation of human platelets stimulated by either modified human immunoglobulin or thrombin. This effect did not involve chelation of calcium or cytotoxicity, and was overcome by larger amounts of the aggregating agents. CRP also inhibited the activation but not the activity of platelet factor 3 and the release of beta-glucuronidase. Thus, CRP can inhibit multiple platelet reactivities. We suggest that this property of CRP may play an important role in the control of platelet responsiveness during reactions of inflammation, defense, and repair.