Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis
Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis
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DOI：
10.1093/rheumatology/keq105
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发表时间：
2010-07-01
期刊：
影响因子：
5.5
通讯作者：
Gladman, Dafna D.
中科院分区：
文献类型：
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作者：
Chandran, Vinod;Cook, Richard J.;Gladman, Dafna D.
目标。生物标志物可能有助于筛选银屑病患者的PSA。我们的目的是确定银屑病和PSA的血清生物标志物。52例银屑病患者(26例符合Caspar PSA分类标准)和26例健康对照被纳入本研究。银屑病患者和PSA患者在年龄、性别和银屑病病程方面匹配，而对照组在年龄和性别上匹配。检测指标：IL-12、IL-12p40、IL-17、肿瘤坏死因子超家族成员14(TNFSF14)、基质金属蛋白酶-3、RANKL、骨保护素(OPG)、软骨低聚基质蛋白(COMP)、II型胶原C-原肽(CPII)、胶原片段新表位COL2-3/4(Long)(Mono)(C2C)、COL2-3/4(Short)(C12C)和高敏C反应蛋白(HsCRP)。对数据进行Logistic回归分析，绘制受试者操作特征曲线。52例银屑病患者的平均年龄为46岁，银屑病病程为16.8年。与对照组相比，血清RANKL、TNFSF14、MMP3和COMP水平升高与银屑病独立相关(P
Objective. Biomarkers may be helpful in screening patients with psoriasis for PsA. Our purpose was to identify serum biomarkers for psoriasis and PsA.Methods. Fifty-two patients with psoriasis (26 satisfying CASPAR classification criteria for PsA) and 26 healthy controls were recruited for our study. Patients with psoriasis and PsA were group matched for age, sex and psoriasis duration, whereas controls were matched for age and sex. Blood samples were drawn at the time of assessment and serum was analysed for the following: IL-12, IL-12p40, IL-17, TNF super family member 14 (TNFSF14), MMP-3, RANK ligand (RANKL), osteoprotegerin (OPG), cartilage oligomeric matrix protein (COMP), C-propeptide of Type II collagen (CPII), collagen fragment neoepitopes Col2-3/4(long) (mono) (C2C) and Col2-3/4(short) (C1-2C) and highly sensitive CRP (hsCRP). Data were analysed using logistic regression and receiver operating characteristic curves were plotted.Results. Fifty-two patients with psoriatic disease had a mean age of 46 years and psoriasis duration of 16.8 years. Compared with controls, increased serum levels of RANKL, TNFSF14, MMP-3 and COMP independently associated with psoriatic disease (P