Nuclear pore complex-mediated gene expression in Arabidopsis thaliana
Nuclear pore complex-mediated gene expression in Arabidopsis thaliana
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DOI：
10.1007/s10265-020-01177-0
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发表时间：
2020-03
影响因子：
2.8
通讯作者：
K. Tamura
中科院分区：
文献类型：
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作者：
K. Tamura
核孔复合物（NPCs）是控制核与细胞质之间大分子双向运输的大型多蛋白复合物。这种贩运受到高度管制，并参与相当广泛的细胞活动，包括植物对病原体的防御反应。最近，NPC正在成为一个将底层染色质与核外周物理联系起来的平台，从而调节染色质结构和基因表达。例如，NPC成分已被证明可以促进特定基因组环的形成，这与基因快速再激活的转录记忆有关。随着新开发的技术和工具，我们在这一领域的洞察力已经大大提高。本文综述了NPC机制作为转录调控枢纽的分子功能的最新研究成果，并比较了植物和非植物生物之间的系统。
Nuclear pore complexes (NPCs) are large multi-protein complexes that control bidirectional trafficking of macromolecules between the nucleus and cytoplasm. This trafficking is highly regulated and participates in a considerably broader range of cellular activities, including defense responses against pathogens in plants. Recently, NPC is emerging as a platform to physically associate the underlying chromatin with the nuclear periphery, thus regulating chromatin structure and gene expression. For instance, NPC components have been shown to promote the formation of specific genomics loops, which is linked to transcriptional memory for rapid reactivation of genes. With newly developed techniques and tools, our insight in this area has been substantially advanced. This review summarizes recent works on the molecular function of NPC machinery as hubs for transcriptional regulation and compares systems between plant and non-plant organisms.