GENETICS OF MIGRAINE AND MIGRAINE ACCOMPAGNEE - A STUDY OF 81 CHILDREN AND THEIR FAMILIES
GENETICS OF MIGRAINE AND MIGRAINE ACCOMPAGNEE - A STUDY OF 81 CHILDREN AND THEIR FAMILIES
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DOI：
10.1055/s-2008-1052549
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发表时间：
1985-01-01
期刊：
影响因子：
1.4
通讯作者：
BAIER, WK
中科院分区：
文献类型：
--
作者：
BAIER, WK
对81例儿童偏头痛患者及其家庭进行了癫痫发作和偏头痛的家族患病率调查。癫痫发作发生率未高于流行病学风险。总的来说，偏头痛很大程度上是遗传自母系，而不考虑首发病例的性别。偏头痛的临床亚型（非局灶性偏头痛和偏头痛伴发）分别不伴有增加的家族患病率。具有较高家族影响的患者偏头痛发病较早。提出偏头痛的多因素发病机制进行了讨论。
Eighty-one patients suffering from childhood onset migraine and their families were investigated for familial prevalences of epileptic seizures and migraine. The incidence of epileptic seizures was not increased above the epidemiological risk. In all, migraine is largely inherited from maternal ascendents, irrespective of the sex of the index case. Clinical subtypes of migraine (non-focal migraine and migraine accompagnee) are not accompanied by, respectively, increased familial prevalences. Onset of migraine is earlier in patients with a higher familial impact. A proposed multifactorial pathogenesis of migraine is discussed.