Osteon interfacial strength and histomorphometry of equine cortical bone
Osteon interfacial strength and histomorphometry of equine cortical bone
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DOI：
10.1016/j.jbiomech.2005.05.006
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Vandenbosch, Ryan
中科院分区：
文献类型：
--
作者：
Bigley, Robert F.;Griffin, Lanny V.;Vandenbosch, Ryan
采用纤维推出试验对纯血马第三掌骨骨干的次级骨单位的界面强度进行了评价。在从皮质的四个解剖区域机加工的4x 4x 15 mm骨块的300-500 μ m切片上进行推出。在偏振光下对每个组织块相邻组织切片上的四种骨单位类型从骨干内近端到远端位置进行了推出强度评价。根据剪力滞理论估算了界面的抗剪强度。在偏振光下的骨单位的界面强度的基础上的外观与明场具有最高的界面强度（40.3 MPa）的差异被发现。暗视野骨单位的强度最低（22.8 MPa）。背侧区域具有最高的剪切强度和韧性相比，所有其他区域。骨水泥线和层间界面的强度相似，但表现出区域依赖性-具体而言，手掌区域强度（17.5 MPa）低于骨单位层间界面（30.4 MPa）和骨单位类型依赖性（交替明显弱于其他类型）。组织形态计量学显示，四种骨单位类型之间的骨单位面积分数存在显著的区域差异（p < 0.0001），骨单位直径也存在差异（p=0.01），背侧区域的骨单位（170 μ m）大于掌侧区域（151 μ m）。疲劳寿命和断裂韧性的哈弗氏骨在文献中报道是区域依赖性的，并已知与骨单位拔出-骨单位界面现象。因此，本研究的结果对于进一步了解皮质骨的脆性和损伤累积机制具有重要意义。(c)2005爱思唯尔有限公司保留所有权利。
The interfacial strength of secondary osteons from the diaphysis of the Thoroughbred equine third metacarpal was evaluated using the fiber pushout test. The pushout was performed on 300-500 mu m sections of 4 x 4 x 15 mm bone blocks machined from four anatomic regions of the cortex. Pushout strength was evaluated from proximal to distal location within the diaphysis on four osteon types classified under polarized light on adjacent histologic sections from each block. The shear strength of the interfaces were estimated from shear lag theory. Differences were found in the interfacial strength of osteons based on appearance under polarized light with bright field having the highest interfacial strength (40.3 MPa). The lowest strength was found in the dark field osteons (22.8 MPa). The dorsal region had the highest shear strength and toughness compared to all other regions. The cement line and interlamellar interfaces are similar in strength, but exhibit regional dependence-specifically, the palmar region strength is less (17.5 MPa) than the osteon interlamellar interfaces (30.4 MPa) and osteon type dependent (alternating significantly weaker than other types). Histomorphometry revealed significant regional differences (p < 0.0001) in osteon area fraction among the four osteon types as well as differences in the osteon diameter (p=0.01), with dorsal regions having larger osteons (170 mu m) than the palmar region (151 mu m). Fatigue life and fracture toughness of Haversian bone are reported in the literature to be regionally dependent and are known to be associated with osteon pullout-an osteon interfacial phenomenon. Therefore, the results presented in this study are important to further the understanding of the mechanisms of fragility and damage accumulation in cortical bone. (c) 2005 Elsevier Ltd. All rights reserved.