A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
复制标题
DOI：
10.1101/gad.10.21.2745
复制
发表时间：
1996-11-01
影响因子：
10.5
通讯作者：
Ip, YT
中科院分区：
文献类型：
--
作者：
Sluss, HK;Han, ZQ;Ip, YT
果蝇MAP激酶DJNK是哺乳动物c-Jun氨基末端激酶（JNK）的同源物。DJNK基因中的突变对应于互补组篮。DJNK被果蝇MAP激酶激酶HEP磷酸化和激活。DJNK的底物包括转录因子DJun。DJNK参与多种生理过程。暴露于内毒素脂多糖引发昆虫免疫应答并导致DJNK活化。此外，缺乏DJNK的胚胎在背侧闭合方面有缺陷，在背侧闭合过程中，外侧上皮细胞在背侧中线处迁移到胚胎和腰部。这些数据表明DJNK信号转导途径介导体内免疫反应和形态发生。
The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking DJNK are defective in dorsal closure, a process in which the lateral epithelial cells migrate over the embryo and loin at the dorsal midline. These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo.