IRON-METABOLISM IN GENETICALLY-OBESE (OB/OB) MICE
IRON-METABOLISM IN GENETICALLY-OBESE (OB/OB) MICE
复制标题
DOI：
10.1093/jn/118.1.46
复制
发表时间：
1988-01-01
影响因子：
4.2
通讯作者：
CHEN, ML
中科院分区：
文献类型：
--
作者：
FAILLA, ML;KENNEDY, ML;CHEN, ML
临床文献中的一些报告表明，肥胖儿童可能有缺铁的风险。这里比较了瘦 (+/?) 和肥胖 (ob/ob) C57BL/6J 小鼠中铁的吸收、保留、组织分布和组织水平，以检查肥胖对该动物模型铁状态的影响。在接受每口含有1μmol铁的溶液后，肥胖小鼠吸收和保留的59Fe大约是瘦小鼠的两倍。这种差异与年龄、肥胖严重程度和胃肠道质量无关。皮下注射1μmol金属后6天，与瘦小鼠相比，随意进食的肥胖小鼠在血液和脂肪垫中具有较高水平的59Fe，但在骨骼肌肉系统中具有较低含量的59Fe。注射后 6 天，肥胖和瘦小鼠的肝脏中至少存在 30% 的尸体 59Fe。尽管肝脏和骨骼中的铁浓度显着降低，但在 10 周龄时，随意喂养的肥胖小鼠的血红蛋白和血细胞比容显着高于瘦小鼠。血浆铁和转铁蛋白不受慢性肥胖的影响。尽管肥胖小鼠和瘦小鼠的铁代谢的几个特征不同，但结果表明，当喂食含有足够水平的这种微量营养素的饮食时，ob/ob 小鼠并不缺铁。肥胖小鼠对铁的吸收增加可能代表了一种适应性反应，为这些动物增加的血容量提供额外的微量营养素。
Several reports in the clinical literature suggest that obese children may be at risk for developing iron deficiency. Here the absorption, retention, tissue distribution and tissue levels of iron were compared in lean (+/?) and obese (ob/ob) C57BL/6J mice to examine the impact of obesity on the iron status of this animal amodel. Obese mice absorbed and retained approximately twice as much 59Fe as lean mice after receiving a solution containing 1 .mu.mol iron per os. This difference was independent of age, severity of obesity and mass of the gastrointestinal tract. Obese mice fed ad libitum had higher levels of 59Fe in blood and fat pads, but lower amounts of 59Fe in the skeletal-muscular system, than lean mice 6 d after subcutaneous injection of 1 .mu.mol of the metal. At least 30% of caarcass 59Fe was present in the liver of obese and lean mice 6 d after injection. Despite significantly lower concentrations of iron in liver and bone, blood hemoglobin and hematocrit were significantly higher in obese mice fed ad libitum than in lean mice at 10 wk of age. Plasma iron and transferrin were not affected by chronic obesity. Although several characteristics of iron metabolism differed in obese and lean mice, the results indicate that ob/ob mice were not iron deficient when fed a diet containing an adequate level of this micronutrient. The increased absorption of iron by obese mice probably represents an adaptive response that is required to supply additional micronutrient for the expanded blood volume in these animals.