Music Therapy Modulates Fronto-Temporal Activity in Rest-EEG in Depressed Clients
Music Therapy Modulates Fronto-Temporal Activity in Rest-EEG in Depressed Clients
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DOI：
10.1007/s10548-012-0254-x
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发表时间：
2013-04-01
期刊：
影响因子：
2.7
通讯作者：
Erkkila, Jaakko
中科院分区：
文献类型：
--
作者：
Fachner, Jorg;Gold, Christian;Erkkila, Jaakko
额颞区处理语音和音乐的共同元素。即兴心理动力音乐疗法（MT）利用语言和音乐对临床即兴创作产生的情感和图像进行反思。听音乐改变了抑郁症患者的额叶α不对称性（FAA），并增加了额叶中线θ（FMT）。在一项包含79名抑郁症患者（伴焦虑症）的双组随机对照试验（RCT）中，我们比较了标准治疗（SC）与MT在SC基础上加用的摄入量和3个月后的结果。我们发现，MT显着减少抑郁和焦虑症状。本研究的目的是测试MT是否对前额颞叶静息态α和θ振荡有影响。探讨前脑电、蒙哥马利-艾斯伯格抑郁量表（MADRS）和医院焦虑抑郁量表-焦虑分量表（HADS-A）的相关性、功率谱分析（地形图、均值、不对称性）和正常脑电图数据库比较。MT 3个月后，观察到静息EEG的持续变化，即，显著的绝对功率在左额颞α增加，但对于θ最明显（也在左额中央和右颞顶导联）。MT与SC在F7-F8（z评分FAA，p < .03）和T3-T4（theta，p < .005）不对称评分上不同，表明MT后相对左侧脑活动减少; MT前/后增加的FMT和减少的HADS-A评分（r = .42，p < .05）表明MT后焦虑减少。言语反射和情绪即兴可能会引起额颞区的神经重组。额颞区和颞顶区的α和θ变化表明MT对抑郁症皮层活动的作用和治疗效果，表明MT对焦虑减少的影响。
Fronto-temporal areas process shared elements of speech and music. Improvisational psychodynamic music therapy (MT) utilizes verbal and musical reflection on emotions and images arising from clinical improvisation. Music listening is shifting frontal alpha asymmetries (FAA) in depression, and increases frontal midline theta (FMT). In a two-armed randomized controlled trial (RCT) with 79 depressed clients (with comorbid anxiety), we compared standard care (SC) versus MT added to SC at intake and after 3 months. We found that MT significantly reduced depression and anxiety symptoms. The purpose of this study is to test whether or not MT has an impact on anterior fronto-temporal resting state alpha and theta oscillations. Correlations between anterior EEG, Montgomery-Asberg Depression Rating Scale (MADRS) and the Hospital Anxiety and Depression Scale-Anxiety Subscale (HADS-A), power spectral analysis (topography, means, asymmetry) and normative EEG database comparisons were explored. After 3 month of MT, lasting changes in resting EEG were observed, i.e., significant absolute power increases at left fronto-temporal alpha, but most distinct for theta (also at left fronto-central and right temporoparietal leads). MT differed to SC at F7-F8 (z scored FAA, p < .03) and T3-T4 (theta, p < .005) asymmetry scores, pointing towards decreased relative left-sided brain activity after MT; pre/post increased FMT and decreased HADS-A scores (r = .42, p < .05) indicate reduced anxiety after MT. Verbal reflection and improvising on emotions in MT may induce neural reorganization in fronto-temporal areas. Alpha and theta changes in fronto-temporal and temporoparietal areas indicate MT action and treatment effects on cortical activity in depression, suggesting an impact of MT on anxiety reduction.