Cortical Network Analysis in Patients Affected by Schizophrenia
Cortical Network Analysis in Patients Affected by Schizophrenia
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DOI：
10.1007/s10548-010-0133-2
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发表时间：
2010-06-01
期刊：
影响因子：
2.7
通讯作者：
Micheloyannis, Sifis
中科院分区：
文献类型：
--
作者：
Fallani, Fabrizio De Vico;Maglione, Antongiulio;Micheloyannis, Sifis
在本研究中，我们研究了一组精神分裂症(SCHZ)患者在2-back工作记忆任务中脑功能网络结构的变化。通过高分辨率脑电技术从头皮脑电信号中获取皮层信号，该技术依赖于逼真的头部模型和线性逆解。通过计算谱的相干性来估计泛函网络。频域中的同步度量--所有可用皮层信号源的时间序列之间的同步。为了分析这些大脑皮层网络，我们遵循了理论图的方法，计算了网络密度作为总的链接数量，以及节点度作为每个大脑皮层来源的链接数量。主要结果表明，在α2频段(11-13 Hz)，SCHZ患者的皮层功能网络与对照组(CTRL)相比差异最大。特别是，SCHZ网络的结构在记忆任务期间发生了根本性的变化，因为与休息条件不同的链接数量相对于CTRL网络敏感地增加了。此外，SCHZ患者在正确执行记忆任务时发现了一种代偿机制，即结节度表现为额叶不对称，左额叶激活程度较高。更高的连接数-在Alpha2频段。
In the present study, we studied the structural changes of the brain functional network in a group of schizophrenic (SCHZ) patients during a 2-back working memory task. Cortical signals were obtained from scalp EEG signals through the high-resolution EEG technique, which relies on realistic head models and linear inverse solutions. Functional networks were estimated by computing the spectral coherence-i.e. a measure of synchronization in the frequency domain-between the time series of all the available cortical sources. To analyze those cortical networks we followed a theoretical graph approach by computing the network density as the total number of links and the node degree as the number of links of each cortical source. The major result suggest that in the Alpha2 frequency band (11-13 Hz) the cortical functional networks of the SCHZ patients present the largest differences when compared with those of a group of control (CTRL) subjects. In particular, the structure of the SCHZ network altered radically during the memory task, as the number of links that were different from the REST condition increased sensibly with respect to the CTRL network. In addition, a compensatory mechanism was found in the SCHZ patients during the correct performance of the memory task where the node degree showed a frontal asymmetry with higher activation of the left frontal lobe-i.e. higher number of connections-in the Alpha2 frequency band.