Role of cell stress signaling networks in cancer cell death and antitumor immune response following proteotoxic injury inflicted by photodynamic therapy
Role of cell stress signaling networks in cancer cell death and antitumor immune response following proteotoxic injury inflicted by photodynamic therapy
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DOI：
10.1002/lsm.22810
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发表时间：
2018-07-01
影响因子：
2.4
通讯作者：
Korbelik, Mladen
中科院分区：
文献类型：
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作者：
Korbelik, Mladen
光动力疗法（PDT）在处理的细胞中递送的损伤是氧化应激。威胁PDT处理细胞存活的主要负担是破坏这些细胞中蛋白质稳态的蛋白毒性损伤。为了应对这种类型的蛋白质稳态损伤，细胞已经开发出通过信号网络操作的保护机制。这篇综述将概述可以参与应激细胞的信号网络的各种组成部分，并强调与PDT反应相关的新兴方面。它也将显示如何众所周知的炎症/免疫反应与PDT也是基于这些应激信号网络的活动。激光外科医学50：491-498，2018。(c)2018年威利期刊公司
The insult delivered by photodynamic therapy (PDT) in treated cells is oxidative stress. The main burden threatening survival of PDT-treated cells is proteotoxic damage that jeopardizes proteostasis in these cells. For dealing with this type of proteostasis impairment, cells have developed protection mechanisms operating by signaling networks. This review will outline various components of signaling networks that can be engaged in stressed cells with highlighting the emerging aspects relevant to response to PDT. It will be also shown how the well known inflammatory/immune response associated with PDT is also based on the activity of these stress signaling networks. Lasers Surg. Med. 50:491-498, 2018. (c) 2018 Wiley Periodicals, Inc.