Tumor Necrosis Factor-alpha Promotes Tumor Growth by Inducing Vascular Endothelial Growth Factor
Tumor Necrosis Factor-alpha Promotes Tumor Growth by Inducing Vascular Endothelial Growth Factor
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肿瘤坏死因子-α通过诱导血管内皮生长因子促进肿瘤生长
DOI：
10.3109/07357907.2011.597812
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发表时间：
2011-08-01
影响因子：
2.4
通讯作者：
Wei, Lixin
中科院分区：
文献类型：
--
作者：
Jing, Yingying;Ma, Nannan;Wei, Lixin
肿瘤坏死因子（TNF）-α已被FDA证明可作为肿瘤的辅助治疗药物。然而，慢性TNF-α表达对肿瘤的影响仍存在争议。在这项研究中，我们研究了低剂量 TNF-α 对肿瘤生长的影响。我们证实，低剂量TNF-α可促进体内肿瘤血管生成，血管内皮生长因子（VEGF）和VEGF转录因子缺氧诱导因子（HIF）-1α均上调。我们的结果表明，低剂量TNF-α是肿瘤血管生成的强大激活剂，而HIF-1α-VEGF途径似乎是最重要的分子机制。
Tumor necrosis factor (TNF)-alpha has been proved as an adjuvant therapy for tumor by FDA. However, the effect of chronic TNF-alpha expression for tumor is still controversial. In this study, we investigated the effect of low-dose TNF-alpha on tumor growth. We confirmed that low-dose TNF-alpha promoted angiogenesis of tumor in vivo, vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1 alpha, the transcription factor of VEGF, were both upregulated. Our results suggested that low-dose TNF-alpha was a powerful activator of angiogenesis in tumor and HIF-1 alpha-VEGF pathway seemed to be the most important molecular mechanism.