Prenatal exposure to a natural disaster increases risk for obesity in 51/2-year-old children
Prenatal exposure to a natural disaster increases risk for obesity in 51/2-year-old children
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DOI：
10.1038/pr.2011.18
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发表时间：
2012-01-01
影响因子：
3.6
通讯作者：
King, Suzanne
中科院分区：
文献类型：
--
作者：
Dancause, Kelsey Needham;Laplante, David P.;King, Suzanne
简介：子宫内的不利环境，包括暴露于产前母体压力（PNMS），可导致出生结果不佳，如出生体重低，这增加了以后患高血压和肥胖症等心脏代谢疾病的风险。目前还不清楚PNMS在多大程度上影响肥胖风险，而不受其对出生特征的影响，特别是在人类中。我们的目的是确定是否PNMS造成的自然灾害影响儿童obesity.RESULTS的风险：8名儿童与高目标PNMS暴露（14.5%）肥胖相比，一个孩子（1.8%）与低暴露（P = 0.02）。目的PNMS增加肥胖风险（模型1，P = 0.02，比值比= 1.37）。讨论：结果表明，PNMS可能是儿童肥胖发展的独立危险因素。参与者包括111名在1998年1月魁北克冰暴期间怀孕或在随后3个月内怀孕的妇女，孩子我们测试了风暴的客观和主观PNMS与51/2岁儿童肥胖状况之间的关联，控制了儿童的出生特征和母乳喂养状况;家庭社会经济状况;产妇产科并发症，生活事件和怀孕期间吸烟，心理功能和身高（模型1，n = 111）或BMI（对于69名参与者的子集，模型2）。
INTRODUCTION: An adverse environment in utero, including exposure to prenatal maternal stress (PNMS), can result in poor birth outcomes such as low birth weight, which increases risk of later cardiometabolic diseases such as hypertension and obesity. It is unclear to what extent PNMS influences obesity risk independent of its impact on birth characteristics, especially among humans. Our objective was to determine whether PNMS resulting from a natural disaster influenced risk of childhood obesity.RESULTS: Eight children with high objective PNMS exposure (14.5%) were obese compared to one child (1.8%) with low exposure (P = 0.02). Objective PNMS increased obesity risk (model 1, P = 0.02, odds ratio = 1.37) after controlling for other potential risk factors.DISCUSSION: Results suggest that PNMS might be an independent risk factor in the development of childhood obesity.METHODS: Participants included 111 women who were pregnant during the January 1998 Quebec Ice Storm or who conceived within the following 3 months and their children. We tested associations between objective and subjective PNMS from the storm and childhood obesity status at age 51/2, controlling for children's birth characteristics and breastfeeding status; household socioeconomic status; maternal obstetric complications, life events and smoking during pregnancy, psychological functioning, and height (model 1, n = 111) or BMI (for a subset of 69 participants, model 2).