Multi-analyte analysis of cytokines that predict outcomes in patients with hepatocellular carcinoma treated with radiotherapy.
Multi-analyte analysis of cytokines that predict outcomes in patients with hepatocellular carcinoma treated with radiotherapy.
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DOI：
10.3748/wjg.v23.i11.2077
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发表时间：
2017-03-21
影响因子：
4.3
通讯作者：
Seong J
中科院分区：
文献类型：
--
作者：
Cha H;Lee EJ;Seong J
分析细胞因子水平，并确定其与放射治疗（RT）的肝细胞癌（HCC）患者的结局之间的关系。接受RT治疗的HCC患者有资格参加这项前瞻性研究。分别于RT前后采集血样，检测血清细胞因子IL-1、IL-6、IL-8、IL-10、IL-12和肿瘤坏死因子-α水平。在2008年至2009年期间，51名患者入组本研究。在有RT前治疗史的患者中，基线IL-6水平较高。中位生存期为13.9个月，甲胎蛋白（AFP）作为一个重要因素（P = 0.020）。内野、外野-肝内和肝外衰竭的中位无衰竭生存期（FFS）分别为23.3、11.5和12.0个月。性别和基线IL-6水平与内场FFS相关，基线IL-10水平与外场-肝内FFS相关。AFP在肝外FFS中有统计学意义（P = 0.034）。基线IL-6水平≥ 9.7 pg/mL的患者表现出更差的内野FFS（P = 0.005），仅在非初治患者中观察到该显著性（P = 0.022）。除AFP外，细胞因子似乎可用于预测内场和外场肝内衰竭。血清细胞因子可能是预测肝癌RT预后的有用生物标志物。
To analyze cytokine levels and to identify their association with outcome in patients with hepatocellular carcinoma (HCC) treated with radiotherapy (RT). Patients with HCC who were treated with RT were eligible for this prospective study. Blood samples were collected before and after RT, and serum cytokine levels including interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor-α were analyzed. Between 2008 and 2009, 51 patients were enrolled in this study. Baseline IL-6 level was high in patients with a history of pre-RT treatment. Median survival was 13.9 mo with alpha-fetoprotein (AFP) as a significant factor (P = 0.020). Median failure-free survival (FFS) for infield, outfield-intrahepatic and extrahepatic failures were 23.3, 11.5 and 12.0 mo, respectively. Sex and baseline IL-6 level were associated with infield FFS, and baseline IL-10 level was correlated with outfield-intrahepatic FFS. For extrahepatic FFS, AFP was significant (P = 0.034). Patients with a baseline IL-6 level of ≥ 9.7 pg/mL showed worse infield FFS (P = 0.005), and this significance was observed only in treatment-non-naïve patients (P = 0.022). In addition to AFP, cytokines seem useful in predicting infield and outfield-intrahepatic failure. Serum cytokines could be useful biomarkers for predicting RT outcome in HCC.
影响因子：
2
作者：
Cha H;Yoon HI;Lee IJ;Koom WS;Han KH;Seong J
通讯作者：
Seong J