Usefulness of MEG magnetometer for spike detection in patients with mesial temporal epileptic focus
Usefulness of MEG magnetometer for spike detection in patients with mesial temporal epileptic focus
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DOI：
10.1016/j.neuroimage.2008.03.038
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发表时间：
2008-07-15
期刊：
影响因子：
5.7
通讯作者：
Hashimoto, N.
中科院分区：
文献类型：
--
作者：
Enatsu, R.;Mikuni, N.;Hashimoto, N.
本研究探讨了脑磁图（MEG）对中颞叶癫痫灶患者不同传感器类型的峰值的敏感性。本文采用磁强计和梯度计两种传感器同时对6例颞叶内侧癫痫灶患者进行脑磁图检测。检测到的尖峰数和相应的等效电流偶极子（ECD）参数（与协调头部中心的距离（半径）和偶极矩）根据传感器类型进行了评估。在3位审稿人确定的426个MEG共识峰值中，378个峰值满足预定的源定位标准。对比ECD参数，磁强计检测到的峰值比梯度计检测到的峰值半径更小，偶极矩更大。磁强计单独检测到的颞内区峰值（38.5%）比单独使用梯度计检测到的峰值（11.5%）要多，而单独使用磁强计检测到的颞外侧区峰值（3.7%）比单独使用梯度计检测到的峰值（53.9%）要少。目前的结果表明，磁强计是有利的尖峰检测患者的内侧颞叶癫痫灶。这也意味着磁强计对深部源具有较高的灵敏度。(c) 2008爱思唯尔公司版权所有。
The present study investigated the sensitivity of magnetoencephalography (MEG) for spikes depending on sensor type in patients with mesial temporal epileptic focus. We recorded MEG in 6 patients with mesial temporal epileptic focus using two sensor types (magnetometer and gradiometer) simultaneously. The number of spikes detected and the corresponding equivalent current dipole (ECD) parameters (distance from the coordinated head center (radius), and dipole moment) were evaluated with respect to sensor type. Among 426 MEG consensus spikes' determined by 3 reviewers, 378 spikes satisfied the predetermined criteria for source localization. Comparing ECD parameters, spikes detected by magnetometer alone displayed a smaller radius and larger dipole moment than those detected by gradiometer alone. Spikes estimated in the mesial temporal area were more frequently detected by magnetometer alone (38.5%) than by gradiometer alone (11.5%), whereas spikes in the lateral temporal area were detected less by magnetometer alone (3.7%) than by gradiometer alone (53.9%). The present results suggest that a magnetometer is advantageous for spike detection in patients with mesial temporal epileptic focus. This also implies the higher sensitivity of magnetometer for deep sources. (c) 2008 Elsevier Inc. All rights reserved.