Signal integration and information transfer in an allosterically regulated network.
Signal integration and information transfer in an allosterically regulated network.
复制标题
变构调节网络中的信号集成和信息传输。
DOI：
10.1038/s41540-019-0100-9
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发表时间：
2019
影响因子：
4
通讯作者：
Lopez,CarlosF
中科院分区：
文献类型：
--
作者：
Shockley,ErinM;Rouzer,CarolA;Marnett,LawrenceJ;Deeds,EricJ;Lopez,CarlosF
生物反应网络可以用于多种目的，处理多于一个输入并通过多于一个输出影响下游过程。这些网络在动态蜂窝环境中操作，其中网络组件的级别可以在小区内和跨小区改变。最近的证据表明，蛋白质浓度的变化可以解释细胞的命运决定。然而，系统具有多个输入，多个输出，并不断变化的输入浓度没有被详细研究，由于其复杂性。在这里，我们采取系统生物化学的方法，结合理化建模和信息论，研究环氧合酶-2（考克斯-2）如何处理复杂的相互作用网络中的同时输入信号。我们发现，输入水平的变化会影响网络传输的信息量，这些输入之间的相关性也会影响。这一点，以及考克斯-2通过其底物的变构调节，使其能够充当对相对输入水平变化最敏感的信号积分器。
A biological reaction network may serve multiple purposes, processing more than one input and impacting downstream processes via more than one output. These networks operate in a dynamic cellular environment in which the levels of network components may change within cells and across cells. Recent evidence suggests that protein concentration variability could explain cell fate decisions. However, systems with multiple inputs, multiple outputs, and changing input concentrations have not been studied in detail due to their complexity. Here, we take a systems biochemistry approach, combining physiochemical modeling and information theory, to investigate how cyclooxygenase-2 (COX-2) processes simultaneous input signals within a complex interaction network. We find that changes in input levels affect the amount of information transmitted by the network, as does the correlation between those inputs. This, and the allosteric regulation of COX-2 by its substrates, allows it to act as a signal integrator that is most sensitive to changes in relative input levels.