Measurement of the thickness of the fibrous cap by optical coherence tomography
Measurement of the thickness of the fibrous cap by optical coherence tomography
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DOI：
10.1016/j.ahj.2006.06.030
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发表时间：
2006-10-01
影响因子：
4.8
通讯作者：
Yoshida, Kiyoshi
中科院分区：
文献类型：
--
作者：
Kume, Teruyoshi;Akasaka, Takashi;Yoshida, Kiyoshi
背景 纤维帽的识别很重要，因为其厚度是富含脂质斑块中斑块脆弱性的主要决定因素。因此，高分辨率成像技术可能是识别富含脂质斑块内纤维帽的有前途的方法。本研究的目的是探讨使用光学相干断层扫描 (OCT) 测量富含脂质斑块内纤维帽厚度的可行性。 方法和结果 我们检查了 38 具人类尸体（22 名男性和 16 名女性；平均年龄为 74 +/- 7 岁）102 个冠状动脉节段的 35 个富含脂质斑块。将光学相干断层扫描和相应的组织学图像数字化，测量纤维帽的厚度，并将OCT与组织学检查的结果进行比较。 OCT 和组织学检查之间的纤维帽厚度具有良好的相关性 (y = 0.97x + 28.49; r = 0.90; P < .001)。 Bland-Altman 测试显示 OCT 和组织学检查之间的纤维帽厚度具有良好的一致性（平均差，-24 +/- 44 μ m）。结论光学相干断层扫描提供了纤维帽厚度的准确表示，并且可能有助于评估富含脂质斑块的斑块脆弱性。
Background Identification of the fibrous cap is important because its thickness is a major determinant of plaque vulnerability in lipid-rich plaque. Thus, a high-resolution imaging technique may be a promising method for the identification of the fibrous cap within lipid-rich plaque. The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to measure the thickness of the fibrous cap within lipid-rich plaque.Methods and Results We examined 35 lipid-rich plaques from 102 coronary arterial segments of 38 human cadavers (22 men and 16 women; mean ages, 74 +/- 7 years). Optical coherence tomography and corresponding histological images were digitized for measurement of the thickness of fibrous cap, and the results between OCT and histological examination were compared. There was good correlation of the thickness of the fibrous cap between OCT and histological examination (y = 0.97x + 28.49; r = 0.90; P < .001). A Bland-Altman test showed good agreement of the thickness of the fibrous cap between OCT and histological examination (mean difference, -24 +/- 44 mu m).Conclusions Optical coherence tomography provides an accurate representation of the thickness of the fibrous cap and may prove useful in assessing plaque vulnerability in lipid-rich plaque.